When one cell is enough

Rhodri Ceredig

doi:10.1186/scrt92

When one cell is enough

Rhodri Ceredig

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

2 Citations (Scopus)

Abstract

For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secondary hosts. That clinical bone marrow transplantation is a successful treatment strategy is indirect evidence that such a cell exists in humans. To date, similar criteria have not been applied to human HSCs. However, using a humanized mouse model of xenotransplantation, a recent paper shows that single human cells can fully reconstitute the lymphomyeloid system of primary recipient animals and, in some cases, that of secondary hosts.

Original language	English
Article number	1
Journal	Stem Cell Research and Therapy
Volume	3
Issue number	3
DOIs	https://doi.org/10.1186/scrt92
Publication status	Published - 1 Jan 2012

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Authors
Ceredig, R

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10.1186/scrt92

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When one cell is enough

Abstract

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