TY - JOUR
T1 - Tuberculosis in Siberia
T2 - 2. Diagnosis, chemoprophylaxis and treatment
AU - Drobniewski, F.
AU - Tayler, E.
AU - Ignatenko, N.
AU - Paul, J.
AU - Connolly, M.
AU - Nye, P.
AU - Lyagoshina, T.
AU - Besse, C.
PY - 1996
Y1 - 1996
N2 - Setting: Siberia, Russian Federation, Objective: To assess tuberculosis diagnosis, chemoprophylaxis and therapy in Siberia as a paradigm for the Russian Federation. Design: Data was obtained from official sources and through visits to dispensaries and hospitals in 1994. Results: Tuberculosis disease and cure is classified according to a Dispensary Group Register based principally on clinical and radiological criteria. Isoniazid is widely used for chemoprophylaxis and post-therapy and may be linked to high levels of isoniazid resistance. Combination drug therapy is individualized, frequently changed, and given orally, parenterally or intra-bronchially. Galvanization, autotransfusion of ultra-violet irradiated blood, antioxidants and steroids are used as adjunct treatment, Ambulatory treatment is uncommon. Surgical treatments including lobectomy and pneumonectomy are used in 5-10% of patients. Conclusion: Tuberculosis is increasing in Siberia. An improved drug supply using short course standardized regimens is required supported by high quality co-ordinated bacteriological services. Surgery retains a useful role, but many adjunct therapies should be abandoned.
AB - Setting: Siberia, Russian Federation, Objective: To assess tuberculosis diagnosis, chemoprophylaxis and therapy in Siberia as a paradigm for the Russian Federation. Design: Data was obtained from official sources and through visits to dispensaries and hospitals in 1994. Results: Tuberculosis disease and cure is classified according to a Dispensary Group Register based principally on clinical and radiological criteria. Isoniazid is widely used for chemoprophylaxis and post-therapy and may be linked to high levels of isoniazid resistance. Combination drug therapy is individualized, frequently changed, and given orally, parenterally or intra-bronchially. Galvanization, autotransfusion of ultra-violet irradiated blood, antioxidants and steroids are used as adjunct treatment, Ambulatory treatment is uncommon. Surgical treatments including lobectomy and pneumonectomy are used in 5-10% of patients. Conclusion: Tuberculosis is increasing in Siberia. An improved drug supply using short course standardized regimens is required supported by high quality co-ordinated bacteriological services. Surgery retains a useful role, but many adjunct therapies should be abandoned.
UR - https://www.scopus.com/pages/publications/0029774073
U2 - 10.1016/S0962-8479(96)90092-1
DO - 10.1016/S0962-8479(96)90092-1
M3 - Article
C2 - 8796243
AN - SCOPUS:0029774073
SN - 0962-8479
VL - 77
SP - 297
EP - 301
JO - Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
JF - Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
IS - 4
ER -
