Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge

Ailbhe M. McDermott; Kah Hoong Chang; Kelly Mieske; Abdelaly Abeidi; Brian H. Harte; Michael J. Kerin; Oliver J. McAnena

doi:10.1016/j.jclinane.2013.07.013

Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge

Ailbhe M. McDermott
, Kah Hoong Chang
, Kelly Mieske
, Abdelaly Abeidi
, Brian H. Harte
, Michael J. Kerin
, Oliver J. McAnena

Surgery

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

11 Citations (Scopus)

Abstract

AbstractStudy Objective To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine. Design Preliminary, prospective, nonrandomized study. Setting Operating room of a university hospital. Patients 5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy. Intervention Five mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation. Measurements Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry. Main Results The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (C_max) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels. Conclusions This preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.

Original language	English
Pages (from-to)	18-24
Number of pages	7
Journal	Journal of Clinical Anesthesia
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.jclinane.2013.07.013
Publication status	Published - 2014

Keywords

Anesthetics, local
Cholecystectomy, laparoscopic
Drug administration routes
Laparoscopy

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10.1016/j.jclinane.2013.07.013

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title = "Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge",

abstract = "AbstractStudy Objective To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine. Design Preliminary, prospective, nonrandomized study. Setting Operating room of a university hospital. Patients 5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy. Intervention Five mL of 1\% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation. Measurements Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry. Main Results The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (Cmax) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels. Conclusions This preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.",

keywords = "Anesthetics, local, Cholecystectomy, laparoscopic, Drug administration routes, Laparoscopy",

author = "McDermott, \{Ailbhe M.\} and Chang, \{Kah Hoong\} and Kelly Mieske and Abdelaly Abeidi and Harte, \{Brian H.\} and Kerin, \{Michael J.\} and McAnena, \{Oliver J.\}",

year = "2014",

doi = "10.1016/j.jclinane.2013.07.013",

language = "English",

volume = "26",

pages = "18--24",

journal = "Journal of Clinical Anesthesia",

issn = "0952-8180",

publisher = "Elsevier Inc.",

number = "1",

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TY - JOUR

T1 - Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge

AU - McDermott, Ailbhe M.

AU - Chang, Kah Hoong

AU - Mieske, Kelly

AU - Abeidi, Abdelaly

AU - Harte, Brian H.

AU - Kerin, Michael J.

AU - McAnena, Oliver J.

PY - 2014

Y1 - 2014

N2 - AbstractStudy Objective To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine. Design Preliminary, prospective, nonrandomized study. Setting Operating room of a university hospital. Patients 5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy. Intervention Five mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation. Measurements Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry. Main Results The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (Cmax) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels. Conclusions This preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.

AB - AbstractStudy Objective To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine. Design Preliminary, prospective, nonrandomized study. Setting Operating room of a university hospital. Patients 5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy. Intervention Five mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation. Measurements Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry. Main Results The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (Cmax) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels. Conclusions This preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.

KW - Anesthetics, local

KW - Cholecystectomy, laparoscopic

KW - Drug administration routes

KW - Laparoscopy

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DO - 10.1016/j.jclinane.2013.07.013

M3 - Article

SN - 0952-8180

VL - 26

SP - 18

EP - 24

JO - Journal of Clinical Anesthesia

JF - Journal of Clinical Anesthesia

IS - 1

ER -

Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge

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Keywords

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