Abstract
Thrombin enhances uterine contractions in animal models, which is an effect that is mediated through protease-activated receptors. The aims of this study were to investigate the effects of thrombin on spontaneous human uterine contractility in vitro, in tissue obtained in the presence and absence of pregnancy, and to investigate the effects of a specific protease-activated receptor 1-activating peptide on human pregnant myometrial contractility.
Original language | English (Ireland) |
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Pages (from-to) | 1098-1105 |
Number of pages | 8 |
Journal | American Journal Of Obstetrics And Gynecology |
Volume | 190 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2004 |
Keywords
- Labor
- Myometrium
- Protease-activated receptors
- Thrombin
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- O'Sullivan CJ, Allen NM, O'Loughlin AJ, Friel AM, Morrison JJ