Thrombin and PAR1-activating peptide: effects on human uterine contractility in vitro. Effects on human uterine contractility in vitro

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Abstract

Thrombin enhances uterine contractions in animal models, which is an effect that is mediated through protease-activated receptors. The aims of this study were to investigate the effects of thrombin on spontaneous human uterine contractility in vitro, in tissue obtained in the presence and absence of pregnancy, and to investigate the effects of a specific protease-activated receptor 1-activating peptide on human pregnant myometrial contractility.
Original languageEnglish (Ireland)
Pages (from-to)1098-1105
Number of pages8
JournalAmerican Journal Of Obstetrics And Gynecology
Volume190
Issue number4
DOIs
Publication statusPublished - 1 Apr 2004

Keywords

  • Labor
  • Myometrium
  • Protease-activated receptors
  • Thrombin

Authors (Note for portal: view the doc link for the full list of authors)

  • Authors
  • O'Sullivan CJ, Allen NM, O'Loughlin AJ, Friel AM, Morrison JJ

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