Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules

Ian Y. Goon; Leo M.H. Lai; Xiaoling Wang; May Lim; Donal Leech; Rose Amal; J. Justin Gooding

doi:10.1109/ICONN.2010.6045171

Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules

Ian Y. Goon, Leo M.H. Lai, Xiaoling Wang, May Lim, Donal Leech, Rose Amal, J. Justin Gooding

Cellular & Molecular Medicine

University of New South Wales

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

3 Citations (Scopus)

Abstract

Gold-coated magnetite nanoparticles (Fe₃O₄-Au _coat NPs) have recently become the focus of research efforts which exploit the novel nano-architecture of these nanoparticles as platforms for magnetically controlled biomedical and analytical applications. To effectively utilise the Fe₃O₄-Au_coat NPs, thiol molecules can be bound onto the gold coating to provide a predictable surface for controlled attachment of functional molecules. Herein we present a facile process by which thiols with different moieties are attached to Fe ₃O₄-Au_coat NPs. Dynamic light scattering and zeta-potential measurements were performed to study the effect of different thiols on the aggregation stability and surface charge of the Fe ₃O₄-Au_coat NPs. The controlled attachment of an electroactive osmium complex is then demonstrated via voltammetric measurements. This work highlights importance of thiol molecule selection in enabling the fabrication of functional Fe₃O₄-Au _coat NPs.

Original language	English
Title of host publication	ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
Pages	45-48
Number of pages	4
DOIs	https://doi.org/10.1109/ICONN.2010.6045171
Publication status	Published - 2010
Event	2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010 - Sydney, NSW, Australia Duration: 22 Feb 2010 → 26 Feb 2010

Publication series

Name	ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

Conference

Conference	2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010
Country/Territory	Australia
City	Sydney, NSW
Period	22/02/10 → 26/02/10

Keywords

Electrochemistry
Gold
Magnetic nanoparticles
Magnetite
Selective functionalisation
Thiols

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10.1109/ICONN.2010.6045171

Cite this

Goon, I. Y., Lai, L. M. H., Wang, X., Lim, M., Leech, D., Amal, R., & Gooding, J. J. (2010). Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology (pp. 45-48). Article 6045171 (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology). https://doi.org/10.1109/ICONN.2010.6045171

Goon, Ian Y. ; Lai, Leo M.H. ; Wang, Xiaoling et al. / Thiol functionalisation of gold-coated magnetic nanoparticles : Enabling the controlled attachment of functional molecules. ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. 2010. pp. 45-48 (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology).

@inproceedings{075e384c91d04957b7a6f0667399eb99,

title = "Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules",

abstract = "Gold-coated magnetite nanoparticles (Fe3O4-Au coat NPs) have recently become the focus of research efforts which exploit the novel nano-architecture of these nanoparticles as platforms for magnetically controlled biomedical and analytical applications. To effectively utilise the Fe3O4-Aucoat NPs, thiol molecules can be bound onto the gold coating to provide a predictable surface for controlled attachment of functional molecules. Herein we present a facile process by which thiols with different moieties are attached to Fe 3O4-Aucoat NPs. Dynamic light scattering and zeta-potential measurements were performed to study the effect of different thiols on the aggregation stability and surface charge of the Fe 3O4-Aucoat NPs. The controlled attachment of an electroactive osmium complex is then demonstrated via voltammetric measurements. This work highlights importance of thiol molecule selection in enabling the fabrication of functional Fe3O4-Au coat NPs.",

keywords = "Electrochemistry, Gold, Magnetic nanoparticles, Magnetite, Selective functionalisation, Thiols",

author = "Goon, \{Ian Y.\} and Lai, \{Leo M.H.\} and Xiaoling Wang and May Lim and Donal Leech and Rose Amal and Gooding, \{J. Justin\}",

year = "2010",

doi = "10.1109/ICONN.2010.6045171",

language = "English",

isbn = "9781424452620",

series = "ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology",

pages = "45--48",

booktitle = "ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology",

note = "2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010 ; Conference date: 22-02-2010 Through 26-02-2010",

}

Goon, IY, Lai, LMH, Wang, X, Lim, M, Leech, D, Amal, R & Gooding, JJ 2010, Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules. in ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology., 6045171, ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology, pp. 45-48, 2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010, Sydney, NSW, Australia, 22/02/10. https://doi.org/10.1109/ICONN.2010.6045171

Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules. / Goon, Ian Y.; Lai, Leo M.H.; Wang, Xiaoling et al.
ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. 2010. p. 45-48 6045171 (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology).

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

TY - GEN

T1 - Thiol functionalisation of gold-coated magnetic nanoparticles

T2 - 2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010

AU - Goon, Ian Y.

AU - Lai, Leo M.H.

AU - Wang, Xiaoling

AU - Lim, May

AU - Leech, Donal

AU - Amal, Rose

AU - Gooding, J. Justin

PY - 2010

Y1 - 2010

N2 - Gold-coated magnetite nanoparticles (Fe3O4-Au coat NPs) have recently become the focus of research efforts which exploit the novel nano-architecture of these nanoparticles as platforms for magnetically controlled biomedical and analytical applications. To effectively utilise the Fe3O4-Aucoat NPs, thiol molecules can be bound onto the gold coating to provide a predictable surface for controlled attachment of functional molecules. Herein we present a facile process by which thiols with different moieties are attached to Fe 3O4-Aucoat NPs. Dynamic light scattering and zeta-potential measurements were performed to study the effect of different thiols on the aggregation stability and surface charge of the Fe 3O4-Aucoat NPs. The controlled attachment of an electroactive osmium complex is then demonstrated via voltammetric measurements. This work highlights importance of thiol molecule selection in enabling the fabrication of functional Fe3O4-Au coat NPs.

AB - Gold-coated magnetite nanoparticles (Fe3O4-Au coat NPs) have recently become the focus of research efforts which exploit the novel nano-architecture of these nanoparticles as platforms for magnetically controlled biomedical and analytical applications. To effectively utilise the Fe3O4-Aucoat NPs, thiol molecules can be bound onto the gold coating to provide a predictable surface for controlled attachment of functional molecules. Herein we present a facile process by which thiols with different moieties are attached to Fe 3O4-Aucoat NPs. Dynamic light scattering and zeta-potential measurements were performed to study the effect of different thiols on the aggregation stability and surface charge of the Fe 3O4-Aucoat NPs. The controlled attachment of an electroactive osmium complex is then demonstrated via voltammetric measurements. This work highlights importance of thiol molecule selection in enabling the fabrication of functional Fe3O4-Au coat NPs.

KW - Electrochemistry

KW - Gold

KW - Magnetic nanoparticles

KW - Magnetite

KW - Selective functionalisation

KW - Thiols

UR - https://www.scopus.com/pages/publications/80555157635

U2 - 10.1109/ICONN.2010.6045171

DO - 10.1109/ICONN.2010.6045171

M3 - Conference Publication

AN - SCOPUS:80555157635

SN - 9781424452620

T3 - ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

SP - 45

EP - 48

BT - ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

Y2 - 22 February 2010 through 26 February 2010

ER -

Goon IY, Lai LMH, Wang X, Lim M, Leech D, Amal R et al. Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. 2010. p. 45-48. 6045171. (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology). doi: 10.1109/ICONN.2010.6045171

Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules

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