The scissors model of microcrack detection in bone: Work in progress

David Taylor; Lauren Mulcahy; Gerardo Presbitero; Pietro Tisbo; Clodagh Dooley; Garry Duffy; T. Clive Lee

doi:10.1557/proc-1274-qq08-01

The scissors model of microcrack detection in bone: Work in progress

David Taylor, Lauren Mulcahy, Gerardo Presbitero, Pietro Tisbo, Clodagh Dooley, Garry Duffy, T. Clive Lee

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

2 Citations (Scopus)

Abstract

We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements of the crack faces are needed to rupture these processes, in an action similar to that of a pair of scissors. Current work involves a combination of cell biology experiments, theoretical and experimental fracture mechanics and system modelling using control theory approaches. The approach will be useful for understanding effects of extreme loading, aging, disease states and drug treatments on bone damage and repair; the present paper presents recent results from experiments and simulations as part of current, ongoing research.

Original language	English
Title of host publication	Biological Materials and Structures in Physiologically Extreme Conditions and Disease
Publisher	Materials Research Society
Pages	103-111
Number of pages	9
ISBN (Print)	9781605112510
DOIs	https://doi.org/10.1557/proc-1274-qq08-01
Publication status	Published - 2010
Externally published	Yes

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1274
ISSN (Print)	0272-9172

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10.1557/proc-1274-qq08-01

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Taylor, D., Mulcahy, L., Presbitero, G., Tisbo, P., Dooley, C., Duffy, G., & Lee, T. C. (2010). The scissors model of microcrack detection in bone: Work in progress. In Biological Materials and Structures in Physiologically Extreme Conditions and Disease (pp. 103-111). (Materials Research Society Symposium Proceedings; Vol. 1274). Materials Research Society. https://doi.org/10.1557/proc-1274-qq08-01

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title = "The scissors model of microcrack detection in bone: Work in progress",

abstract = "We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements of the crack faces are needed to rupture these processes, in an action similar to that of a pair of scissors. Current work involves a combination of cell biology experiments, theoretical and experimental fracture mechanics and system modelling using control theory approaches. The approach will be useful for understanding effects of extreme loading, aging, disease states and drug treatments on bone damage and repair; the present paper presents recent results from experiments and simulations as part of current, ongoing research.",

author = "David Taylor and Lauren Mulcahy and Gerardo Presbitero and Pietro Tisbo and Clodagh Dooley and Garry Duffy and Lee, \{T. Clive\}",

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doi = "10.1557/proc-1274-qq08-01",

language = "English",

isbn = "9781605112510",

series = "Materials Research Society Symposium Proceedings",

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Taylor, D, Mulcahy, L, Presbitero, G, Tisbo, P, Dooley, C, Duffy, G & Lee, TC 2010, The scissors model of microcrack detection in bone: Work in progress. in Biological Materials and Structures in Physiologically Extreme Conditions and Disease. Materials Research Society Symposium Proceedings, vol. 1274, Materials Research Society, pp. 103-111. https://doi.org/10.1557/proc-1274-qq08-01

The scissors model of microcrack detection in bone: Work in progress. / Taylor, David; Mulcahy, Lauren; Presbitero, Gerardo et al.
Biological Materials and Structures in Physiologically Extreme Conditions and Disease. Materials Research Society, 2010. p. 103-111 (Materials Research Society Symposium Proceedings; Vol. 1274).

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

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AB - We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements of the crack faces are needed to rupture these processes, in an action similar to that of a pair of scissors. Current work involves a combination of cell biology experiments, theoretical and experimental fracture mechanics and system modelling using control theory approaches. The approach will be useful for understanding effects of extreme loading, aging, disease states and drug treatments on bone damage and repair; the present paper presents recent results from experiments and simulations as part of current, ongoing research.

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The scissors model of microcrack detection in bone: Work in progress

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