The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction

Xiaoju Shi; Shirley A. Hanley; Marie Claire Faray-Kele; Stuart C. Fawell; Joseph Aduse-Opoku; Robert A. Whiley; Michael A. Curtis; Lucinda M.C. Hall

doi:10.1128/IAI.01785-06

The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction

Xiaoju Shi
, Shirley A. Hanley
, Marie Claire Faray-Kele
, Stuart C. Fawell
, Joseph Aduse-Opoku
, Robert A. Whiley
, Michael A. Curtis
, Lucinda M.C. Hall

Barts and The London School of Medicine and Dentistry
Beckman Coulter

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

25 Citations (Scopus)

Abstract

The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.

Original language	English
Pages (from-to)	2071-2074
Number of pages	4
Journal	Infection and Immunity
Volume	75
Issue number	4
DOIs	https://doi.org/10.1128/IAI.01785-06
Publication status	Published - Apr 2007
Externally published	Yes

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title = "The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction",

abstract = "The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.",

author = "Xiaoju Shi and Hanley, \{Shirley A.\} and Faray-Kele, \{Marie Claire\} and Fawell, \{Stuart C.\} and Joseph Aduse-Opoku and Whiley, \{Robert A.\} and Curtis, \{Michael A.\} and Hall, \{Lucinda M.C.\}",

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T1 - The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction

AU - Shi, Xiaoju

AU - Hanley, Shirley A.

AU - Faray-Kele, Marie Claire

AU - Fawell, Stuart C.

AU - Aduse-Opoku, Joseph

AU - Whiley, Robert A.

AU - Curtis, Michael A.

AU - Hall, Lucinda M.C.

PY - 2007/4

Y1 - 2007/4

N2 - The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.

AB - The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.

UR - https://www.scopus.com/pages/publications/34147167080

U2 - 10.1128/IAI.01785-06

DO - 10.1128/IAI.01785-06

M3 - Article

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AN - SCOPUS:34147167080

SN - 0019-9567

VL - 75

SP - 2071

EP - 2074

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction

Abstract

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