The pathophysiology of otosclerosis: Review of current research

Ivan James Keogh

doi:10.1016/j.heares.2015.07.014

The pathophysiology of otosclerosis: Review of current research

Ivan James Keogh

Surgery

Research output: Other contribution (Published) › Other contribution

Abstract

Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways. This article is part of a Special Issue entitled IEB Kyoto. (C) 2015 Elsevier B.V. All rights reserved.

Original language	English (Ireland)
Media of output	Reviews
Volume	330
DOIs	https://doi.org/10.1016/j.heares.2015.07.014
Publication status	Published - 1 Dec 2015

Access to Document

10.1016/j.heares.2015.07.014

Cite this

@misc{49bfca3e6cff46b59e17d6b7249ffdf1,

title = "The pathophysiology of otosclerosis: Review of current research",

abstract = "Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways. This article is part of a Special Issue entitled IEB Kyoto. (C) 2015 Elsevier B.V. All rights reserved.",

author = "Keogh, \{Ivan James\}",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.heares.2015.07.014",

language = "English (Ireland)",

volume = "330",

type = "Other",

}

TY - GEN

T1 - The pathophysiology of otosclerosis: Review of current research

AU - Keogh, Ivan James

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways. This article is part of a Special Issue entitled IEB Kyoto. (C) 2015 Elsevier B.V. All rights reserved.

AB - Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways. This article is part of a Special Issue entitled IEB Kyoto. (C) 2015 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.heares.2015.07.014

DO - 10.1016/j.heares.2015.07.014

M3 - Other contribution

VL - 330

ER -

The pathophysiology of otosclerosis: Review of current research

Abstract

Access to Document

Fingerprint

Cite this