The past, present and future in scaffold-based tendon treatments

Manus Biggs; Abhay Shashikant Pandit; Leo Quinlan; Dimitrios Zeugolis; Gearid  Laighin

doi:10.1016/j.addr.2014.11.022

The past, present and future in scaffold-based tendon treatments

Manus Biggs, Abhay Shashikant Pandit, Leo Quinlan, Dimitrios Zeugolis, Gearid Laighin

Research output: Other contribution (Published) › Other contribution

Abstract

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.

Original language	English (Ireland)
Media of output	Reviews
Publisher	ELSEVIER SCIENCE BV
Volume	84
ISBN (Print)	0169-409X
ISBN (Electronic)	0169-409X
DOIs	https://doi.org/10.1016/j.addr.2014.11.022
Publication status	Published - 1 Apr 2015

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title = "The past, present and future in scaffold-based tendon treatments",

abstract = "Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.",

author = "Manus Biggs and Pandit, \{Abhay Shashikant\} and Leo Quinlan and Dimitrios Zeugolis and Gearid Laighin",

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T1 - The past, present and future in scaffold-based tendon treatments

AU - Biggs, Manus

AU - Pandit, Abhay Shashikant

AU - Quinlan, Leo

AU - Zeugolis, Dimitrios

AU - Laighin, Gearid

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.

AB - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.addr.2014.11.022

DO - 10.1016/j.addr.2014.11.022

M3 - Other contribution

SN - 0169-409X

VL - 84

PB - ELSEVIER SCIENCE BV

ER -

The past, present and future in scaffold-based tendon treatments

Abstract

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