The past, present and future in scaffold-based tendon treatments

A. J. Lomas; C. N.M. Ryan; A. Sorushanova; N. Shologu; A. I. Sideri; V. Tsioli; G. C. Fthenakis; A. Tzora; I. Skoufos; L. R. Quinlan; G. O'Laighin; A. M. Mullen; J. L. Kelly; S. Kearns; M. Biggs; A. Pandit; D. I. Zeugolis

doi:10.1016/j.addr.2014.11.022

The past, present and future in scaffold-based tendon treatments

A. J. Lomas, C. N.M. Ryan, A. Sorushanova, N. Shologu, A. I. Sideri, V. Tsioli, G. C. Fthenakis, A. Tzora, I. Skoufos, L. R. Quinlan, G. O'Laighin, A. M. Mullen, J. L. Kelly, S. Kearns, M. Biggs, A. Pandit, D. I. Zeugolis

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

181 Citations (Scopus)

Abstract

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

Original language	English
Pages (from-to)	257-277
Number of pages	21
Journal	Advanced Drug Delivery Reviews
Volume	84
DOIs	https://doi.org/10.1016/j.addr.2014.11.022
Publication status	Published - 1 Apr 2015

Keywords

Biomaterials
Human and equine tendon injury
Sustained and localised delivery of therapeutics/biologics
Tendon cellular and extracellular composition
Tendon healing
Tissue grafts

Access to Document

10.1016/j.addr.2014.11.022

Cite this

Lomas, A. J., Ryan, C. N. M., Sorushanova, A., Shologu, N., Sideri, A. I., Tsioli, V., Fthenakis, G. C., Tzora, A., Skoufos, I., Quinlan, L. R., O'Laighin, G., Mullen, A. M., Kelly, J. L., Kearns, S., Biggs, M., Pandit, A., & Zeugolis, D. I. (2015). The past, present and future in scaffold-based tendon treatments. Advanced Drug Delivery Reviews, 84, 257-277. https://doi.org/10.1016/j.addr.2014.11.022

@article{0290272a47fd4e4fa5079b15a684ac13,

title = "The past, present and future in scaffold-based tendon treatments",

abstract = "Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.",

keywords = "Biomaterials, Human and equine tendon injury, Sustained and localised delivery of therapeutics/biologics, Tendon cellular and extracellular composition, Tendon healing, Tissue grafts",

author = "Lomas, \{A. J.\} and Ryan, \{C. N.M.\} and A. Sorushanova and N. Shologu and Sideri, \{A. I.\} and V. Tsioli and Fthenakis, \{G. C.\} and A. Tzora and I. Skoufos and Quinlan, \{L. R.\} and G. O'Laighin and Mullen, \{A. M.\} and Kelly, \{J. L.\} and S. Kearns and M. Biggs and A. Pandit and Zeugolis, \{D. I.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.addr.2014.11.022",

language = "English",

volume = "84",

pages = "257--277",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

}

Lomas, AJ, Ryan, CNM, Sorushanova, A, Shologu, N, Sideri, AI, Tsioli, V, Fthenakis, GC, Tzora, A, Skoufos, I, Quinlan, LR, O'Laighin, G, Mullen, AM, Kelly, JL, Kearns, S , Biggs, M, Pandit, A & Zeugolis, DI 2015, 'The past, present and future in scaffold-based tendon treatments', Advanced Drug Delivery Reviews, vol. 84, pp. 257-277. https://doi.org/10.1016/j.addr.2014.11.022

TY - JOUR

T1 - The past, present and future in scaffold-based tendon treatments

AU - Lomas, A. J.

AU - Ryan, C. N.M.

AU - Sorushanova, A.

AU - Shologu, N.

AU - Sideri, A. I.

AU - Tsioli, V.

AU - Fthenakis, G. C.

AU - Tzora, A.

AU - Skoufos, I.

AU - Quinlan, L. R.

AU - O'Laighin, G.

AU - Mullen, A. M.

AU - Kelly, J. L.

AU - Kearns, S.

AU - Biggs, M.

AU - Pandit, A.

AU - Zeugolis, D. I.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

AB - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

KW - Biomaterials

KW - Human and equine tendon injury

KW - Sustained and localised delivery of therapeutics/biologics

KW - Tendon cellular and extracellular composition

KW - Tendon healing

KW - Tissue grafts

UR - http://www.scopus.com/inward/record.url?scp=84929129331&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2014.11.022

DO - 10.1016/j.addr.2014.11.022

M3 - Review article

SN - 0169-409X

VL - 84

SP - 257

EP - 277

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

The past, present and future in scaffold-based tendon treatments

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this