The past, present and future in scaffold-based tendon treatments

A. J. Lomas; C. N. M. Ryan; A. Sorushanova; Naledi Shologu; A. I. Sideri; V. Tsioli; G. C. Fthenakis; Athina Tzora; Ioannis Skoufos; Leo R. Quinlan; Gearóid Ó Laighin; A. M. Mullen; A. M. Kelly; J. L. Kearns; S. Biggs; Abhay S. Pandit; Dimitrios I. Zeugolis

doi:10.13025/18124

The past, present and future in scaffold-based tendon treatments

A. J. Lomas
, C. N. M. Ryan
, A. Sorushanova
, Naledi Shologu
, A. I. Sideri
, V. Tsioli
, G. C. Fthenakis
, Athina Tzora
, Ioannis Skoufos
, Leo R. Quinlan
, Gearóid Ó Laighin
, A. M. Mullen
, A. M. Kelly
, J. L. Kearns
, S. Biggs
, Abhay S. Pandit
, Dimitrios I. Zeugolis

University of Galway
University of Thessaly
TEI of Epirus
Teagasc Research Centre

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

204 Citations (Scopus)

11 Downloads (Pure)

Abstract

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

Original language	English (Ireland)
Pages (from-to)	257-277
Number of pages	21
Journal	Advanced Drug Delivery Reviews
Volume	84
DOIs	https://doi.org/10.13025/18124 https://doi.org/10.1016/j.addr.2014.11.022
Publication status	Published - 1 Apr 2015

Keywords

ANTERIOR CRUCIATE-LIGAMENT
Biomaterials
DIGITAL FLEXOR TENDON
GROWTH-FACTOR SUPPLEMENTATION
HUMAN ACHILLES-TENDON
Human and equine tendon injury
MARROW STROMAL CELLS
MESENCHYMAL STEM-CELLS
PLATELET-RICH PLASMA
PROXIMAL SUSPENSORY DESMITIS
ROTATOR CUFF REPAIR
Sustained and localised delivery of therapeutics/biologics
Tendon cellular and extracellular composition
Tendon healing
TISSUE ENGINEERING APPLICATIONS
Tissue grafts

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10.13025/18124Licence: CC BY
10.1016/j.addr.2014.11.022

08-11-2014 DZ Edit - ADDR - Alex ManuscriptAccepted author manuscript, 2.05 MBLicence: CC BY

Cite this

Lomas, A. J., Ryan, C. N. M., Sorushanova, A., Shologu, N., Sideri, A. I., Tsioli, V., Fthenakis, G. C., Tzora, A., Skoufos, I., Quinlan, L. R., Ó Laighin, G., Mullen, A. M., Kelly, A. M., Kearns, J. L., Biggs, S., Pandit, A. S., & Zeugolis, D. I. (2015). The past, present and future in scaffold-based tendon treatments. Advanced Drug Delivery Reviews, 84, 257-277. https://doi.org/10.13025/18124, https://doi.org/10.1016/j.addr.2014.11.022

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title = "The past, present and future in scaffold-based tendon treatments",

abstract = "Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.",

keywords = "ANTERIOR CRUCIATE-LIGAMENT, Biomaterials, DIGITAL FLEXOR TENDON, GROWTH-FACTOR SUPPLEMENTATION, HUMAN ACHILLES-TENDON, Human and equine tendon injury, MARROW STROMAL CELLS, MESENCHYMAL STEM-CELLS, PLATELET-RICH PLASMA, PROXIMAL SUSPENSORY DESMITIS, ROTATOR CUFF REPAIR, Sustained and localised delivery of therapeutics/biologics, Tendon cellular and extracellular composition, Tendon healing, TISSUE ENGINEERING APPLICATIONS, Tissue grafts",

author = "Lomas, \{A. J.\} and Ryan, \{C. N. M.\} and A. Sorushanova and Naledi Shologu and Sideri, \{A. I.\} and V. Tsioli and Fthenakis, \{G. C.\} and Athina Tzora and Ioannis Skoufos and Quinlan, \{Leo R.\} and \{{\'O} Laighin\}, Gear{\'o}id and Mullen, \{A. M.\} and Kelly, \{A. M.\} and Kearns, \{J. L.\} and S. Biggs and Pandit, \{Abhay S.\} and Zeugolis, \{Dimitrios I.\}",

year = "2015",

month = apr,

day = "1",

doi = "10.13025/18124",

language = "English (Ireland)",

volume = "84",

pages = "257--277",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

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Lomas, AJ, Ryan, CNM, Sorushanova, A, Shologu, N, Sideri, AI, Tsioli, V, Fthenakis, GC, Tzora, A, Skoufos, I, Quinlan, LR, Ó Laighin, G, Mullen, AM, Kelly, AM, Kearns, JL, Biggs, S, Pandit, AS & Zeugolis, DI 2015, 'The past, present and future in scaffold-based tendon treatments', Advanced Drug Delivery Reviews, vol. 84, pp. 257-277. https://doi.org/10.13025/18124, https://doi.org/10.1016/j.addr.2014.11.022

TY - JOUR

T1 - The past, present and future in scaffold-based tendon treatments

AU - Lomas, A. J.

AU - Ryan, C. N. M.

AU - Sorushanova, A.

AU - Shologu, Naledi

AU - Sideri, A. I.

AU - Tsioli, V.

AU - Fthenakis, G. C.

AU - Tzora, Athina

AU - Skoufos, Ioannis

AU - Quinlan, Leo R.

AU - Ó Laighin, Gearóid

AU - Mullen, A. M.

AU - Kelly, A. M.

AU - Kearns, J. L.

AU - Biggs, S.

AU - Pandit, Abhay S.

AU - Zeugolis, Dimitrios I.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

AB - Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

KW - ANTERIOR CRUCIATE-LIGAMENT

KW - Biomaterials

KW - DIGITAL FLEXOR TENDON

KW - GROWTH-FACTOR SUPPLEMENTATION

KW - HUMAN ACHILLES-TENDON

KW - Human and equine tendon injury

KW - MARROW STROMAL CELLS

KW - MESENCHYMAL STEM-CELLS

KW - PLATELET-RICH PLASMA

KW - PROXIMAL SUSPENSORY DESMITIS

KW - ROTATOR CUFF REPAIR

KW - Sustained and localised delivery of therapeutics/biologics

KW - Tendon cellular and extracellular composition

KW - Tendon healing

KW - TISSUE ENGINEERING APPLICATIONS

KW - Tissue grafts

UR - http://hdl.handle.net/10379/7113

UR - https://www.scopus.com/pages/publications/84929129331

U2 - 10.13025/18124

DO - 10.13025/18124

M3 - Article

SN - 0169-409X

VL - 84

SP - 257

EP - 277

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

The past, present and future in scaffold-based tendon treatments

Abstract

Keywords

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