Abstract
There exist three highly-conserved structural maintenance of chromosomes (Smc) complexes that ensure genome stability during eukaryotic cell division. There are the well-characterized cohesin and condensin complexes and the third Smc complex, Smc5/6. Nse2/Mms21, a SUMO ligase, is a component of the Smc5/6 complex and recent data have indicated that Nse1 may function as a ubiquitin ligase. Smc5/6 regulates sister chromatid cohesion, homologous recombination and chromatin structure and conformation. This review examines the functions of Smc5/6 in DNA repair and the maintenance of genomic integrity and explores the roles of the associated SUMO and ubiquitin ligases. Recent findings have indicated that Smc5/6 may play a topological role in chromosome dynamics, which may help understand the complexity of its activities.
| Original language | English |
|---|---|
| Pages (from-to) | 2907-2913 |
| Number of pages | 7 |
| Journal | FEBS Letters |
| Volume | 585 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 16 Sep 2011 |
Keywords
- Cohesin
- DNA double-strand break repair
- Homologous recombination
- SMC proteins
- SUMO ligase
Fingerprint
Dive into the research topics of 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver