The MAS proto-oncogene is imprinted in human breast tissue

Nicola Miller; Amanda H. McCann; David Connell; Inge S. Pedersen; Valerie Spiers; Thomas Gorey; Peter A. Dervan

doi:10.1006/geno.1997.5063

The MAS proto-oncogene is imprinted in human breast tissue

Nicola Miller
, Amanda H. McCann
, David Connell
, Inge S. Pedersen
, Valerie Spiers
, Thomas Gorey
, Peter A. Dervan

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

22 Citations (Scopus)

Abstract

The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT- PCR product, 4 were informative for a polymorphic marker. In all 4 eases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue.

Original language	English
Pages (from-to)	509-512
Number of pages	4
Journal	Genomics
Volume	46
Issue number	3
DOIs	https://doi.org/10.1006/geno.1997.5063
Publication status	Published - 15 Dec 1997
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1006/geno.1997.5063

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title = "The MAS proto-oncogene is imprinted in human breast tissue",

abstract = "The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT- PCR product, 4 were informative for a polymorphic marker. In all 4 eases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue.",

author = "Nicola Miller and McCann, \{Amanda H.\} and David Connell and Pedersen, \{Inge S.\} and Valerie Spiers and Thomas Gorey and Dervan, \{Peter A.\}",

year = "1997",

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doi = "10.1006/geno.1997.5063",

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T1 - The MAS proto-oncogene is imprinted in human breast tissue

AU - Miller, Nicola

AU - McCann, Amanda H.

AU - Connell, David

AU - Pedersen, Inge S.

AU - Spiers, Valerie

AU - Gorey, Thomas

AU - Dervan, Peter A.

PY - 1997/12/15

Y1 - 1997/12/15

N2 - The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT- PCR product, 4 were informative for a polymorphic marker. In all 4 eases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue.

AB - The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT- PCR product, 4 were informative for a polymorphic marker. In all 4 eases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue.

UR - https://www.scopus.com/pages/publications/0031573792

U2 - 10.1006/geno.1997.5063

DO - 10.1006/geno.1997.5063

M3 - Article

SN - 0888-7543

VL - 46

SP - 509

EP - 512

JO - Genomics

JF - Genomics

IS - 3

ER -

The MAS proto-oncogene is imprinted in human breast tissue

Abstract

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