The key role of IL-7 in lymphopoiesis

Rhodri Ceredig

doi:10.1016/j.smim.2012.02.004

The key role of IL-7 in lymphopoiesis

Rhodri Ceredig

Medicine

Research output: Other contribution (Published) › Other contribution

Abstract

In mice, Interleukin 7, although initially thought to be predominantly a cytokine acting on B cells, appears to have potent survival and growth activity during both B and T lymphopoiesis. Although acting on both lineages at the very immature stages, T cell differentiation becomes independent of IL-7 at the intermediate stages before regaining dependence on IL-7 for survival and proliferation at the mature T cell stage. In contrast, although essential for B lymphopoiesis, mature B cell survival is independent of IL-7. In this review, we focus on and discuss the similarities and differences between the role of IL-7 in these two processes. (C) 2012 Elsevier Ltd. All rights reserved.

Original language	English (Ireland)
Media of output	Reviews
Volume	24
DOIs	https://doi.org/10.1016/j.smim.2012.02.004
Publication status	Published - 1 Jun 2012

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title = "The key role of IL-7 in lymphopoiesis",

abstract = "In mice, Interleukin 7, although initially thought to be predominantly a cytokine acting on B cells, appears to have potent survival and growth activity during both B and T lymphopoiesis. Although acting on both lineages at the very immature stages, T cell differentiation becomes independent of IL-7 at the intermediate stages before regaining dependence on IL-7 for survival and proliferation at the mature T cell stage. In contrast, although essential for B lymphopoiesis, mature B cell survival is independent of IL-7. In this review, we focus on and discuss the similarities and differences between the role of IL-7 in these two processes. (C) 2012 Elsevier Ltd. All rights reserved.",

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AB - In mice, Interleukin 7, although initially thought to be predominantly a cytokine acting on B cells, appears to have potent survival and growth activity during both B and T lymphopoiesis. Although acting on both lineages at the very immature stages, T cell differentiation becomes independent of IL-7 at the intermediate stages before regaining dependence on IL-7 for survival and proliferation at the mature T cell stage. In contrast, although essential for B lymphopoiesis, mature B cell survival is independent of IL-7. In this review, we focus on and discuss the similarities and differences between the role of IL-7 in these two processes. (C) 2012 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.smim.2012.02.004

DO - 10.1016/j.smim.2012.02.004

M3 - Other contribution

VL - 24

ER -

The key role of IL-7 in lymphopoiesis

Abstract

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