@article{e6f71c30aec54346bb1b3e7559b76520,
title = "The impact of viral mutations on recognition by SARS-CoV-2 specific T cells",
abstract = "We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.",
keywords = "Immune response, Immunology, Molecular biology, Phylogenetics, Virology",
author = "\{COVID-19 Genomics UK (COG-UK) Consortium\} and \{ISARIC4C Investigators\} and \{de Silva\}, \{Thushan I.\} and Guihai Liu and Lindsey, \{Benjamin B.\} and Danning Dong and Moore, \{Shona C.\} and Hsu, \{Nienyun Sharon\} and Dhruv Shah and Dannielle Wellington and Mentzer, \{Alexander J.\} and Adrienn Angyal and Rebecca Brown and Parker, \{Matthew D.\} and Zixi Ying and Xuan Yao and Lance Turtle and Susanna Dunachie and Aanensen, \{David M.\} and Khalil Abudahab and Helen Adams and Alexander Adams and Safiah Afifi and Dinesh Aggarwal and Ahmad, \{Shazaad S.Y.\} and Louise Aigrain and Adela Alcolea-Medina and Alikhan, \{Nabil Fareed\} and Elias Allara and Roberto Amato and Tara Annett and Stephen Aplin and Ariani, \{Cristina V.\} and Hibo Asad and Amy Ash and Paula Ashfield and Fiona Ashford and Laura Atkinson and Attwood, \{Stephen W.\} and Cressida Auckland and Alp Aydin and Baker, \{David J.\} and Paul Baker and Balcazar, \{Carlos E.\} and Jonathan Ball and Barrett, \{Jeffrey C.\} and Magdalena Barrow and Edward Barton and Matthew Bashton and Bassett, \{Andrew R.\} and Rahul Batra and Chris Baxter and Nadua Bayzid and Charlotte Beaver and Beckett, \{Angela H.\} and Beckwith, \{Shaun M.\} and Luke Bedford and Robert Beer and Andrew Beggs and Bellis, \{Katherine L.\} and Louise Berry and Beatrice Bertolusso and Angus Best and Emma Betteridge and David Bibby and Kelly Bicknell and Debbie Binns and Alec Birchley and Bird, \{Paul W.\} and Chloe Bishop and Rachel Blacow and Victoria Blakey and Beth Blane and Frances Bolt and James Bonfield and Stephen Bonner and David Bonsall and Tim Boswell and Andrew Bosworth and Yann Bourgeois and Olivia Boyd and Bradley, \{Declan T.\} and Cassie Breen and Catherine Bresner and Judith Breuer and Stephen Bridgett and Bronner, \{Iraad F.\} and Ellena Brooks and Alice Broos and Brown, \{Julianne R.\} and Giselda Bucca and Buchan, \{Sarah L.\} and David Buck and Matthew Bull and Burns, \{Phillipa J.\} and Shirelle Burton-Fanning and Timothy Byaruhanga and Matthew Byott and Sharon Campbell and Carabelli, \{Alessandro M.\} and Cargill, \{James S.\} and Dorman, \{Matthew J.\}",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = nov,
day = "19",
doi = "10.1016/j.isci.2021.103353",
language = "English",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}
