The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats

Karen L. Smith; Michelle Roche; David S. Jessop; David P. Finn

doi:10.1016/j.euroneuro.2009.01.005

The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats

Karen L. Smith, Michelle Roche, David S. Jessop, David P. Finn

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

6 Citations (Scopus)

Abstract

We have mapped Fos expression to investigate brain regions activated by synthetic selective I₂ (BU224) and endogenous (harmane) imidazoline binding site ligands in naive and restraint-stressed rats. Systemic administration of BU224 or harmane to naive rats increased Fos-like immunoreactivity (FLI) in the hypothalamic paraventricular nucleus (PVN), hippocampal dentate gyrus (DG), central and medial nuclei of the amygdala (CeA, MeA) and the locus coeruleus (LC). FLI in restraint-stressed rats was increased in all 5 regions by harmane, and in the CeA, MeA and LC by BU224. Dual-labelling of FLI cells in the PVN of naive rats showed an increase in the number of corticotrophin-releasing-factor-containing cells (CRF) activated by BU224 and harmane. Several CRF-containing neurons in the PVN expressed α₁-adrenoceptors and were densely surrounded by catecholaminergic axons and terminals. Our results provide a functional neuroanatomical framework which may explain the stimulatory effects of imidazoline ligands on basal and stress-induced neuronal and neuroendocrine activity.

Original language	English
Pages (from-to)	371-380
Number of pages	10
Journal	European Neuropsychopharmacology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.euroneuro.2009.01.005
Publication status	Published - 1 May 2009

Keywords

Brain
Imidazoline binding sites
Limbic system
Rat
Restraint stress
c-Fos

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Smith, KL;Roche, M;Jessop, DS;Finn, DP

Access to Document

10.1016/j.euroneuro.2009.01.005

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title = "The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats",

abstract = "We have mapped Fos expression to investigate brain regions activated by synthetic selective I2 (BU224) and endogenous (harmane) imidazoline binding site ligands in naive and restraint-stressed rats. Systemic administration of BU224 or harmane to naive rats increased Fos-like immunoreactivity (FLI) in the hypothalamic paraventricular nucleus (PVN), hippocampal dentate gyrus (DG), central and medial nuclei of the amygdala (CeA, MeA) and the locus coeruleus (LC). FLI in restraint-stressed rats was increased in all 5 regions by harmane, and in the CeA, MeA and LC by BU224. Dual-labelling of FLI cells in the PVN of naive rats showed an increase in the number of corticotrophin-releasing-factor-containing cells (CRF) activated by BU224 and harmane. Several CRF-containing neurons in the PVN expressed α1-adrenoceptors and were densely surrounded by catecholaminergic axons and terminals. Our results provide a functional neuroanatomical framework which may explain the stimulatory effects of imidazoline ligands on basal and stress-induced neuronal and neuroendocrine activity.",

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The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats. / Smith, Karen L.; Roche, Michelle; Jessop, David S. et al.
In: European Neuropsychopharmacology, Vol. 19, No. 5, 01.05.2009, p. 371-380.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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AU - Jessop, David S.

AU - Finn, David P.

PY - 2009/5/1

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The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats

Abstract

Keywords

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