Abstract
The effect of 2-amino-3-phosphonopropionate (AP-3), a metabotropic glutamate receptor antagonist on behavioural and histological changes following global ischaemia was investigated on the Mongolian gerbil. Ischaemia was induced by bilateral carotid occlusion for 5 min. AP-3 was administered i.p. (25 or 250 mg kg) 30 min before and 24 h after surgery. Significant neuroprotection was observed 96 h after surgery to cells in the CA1 region of the hippocampus in drug treated animals. AP-3 (250 mg kg) significantly attenuated the increase in locomotor activity measured 72 h after surgery. These results suggest that metabotropic glutamate receptors play a role in the neurodegeneration seen following ischaemia.
| Original language | English (Ireland) |
|---|---|
| Title of host publication | THE EFFECT OF 2-AMINO-3-PHOSPHONOPROPIONIC ACID (AP-3) IN THE GERBIL MODEL OF CEREBRAL-ISCHEMIA |
| Publication status | Published - 1 Aug 1995 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- MAGINN, M;CALDWELL, M;KELLY, JP;LEONARD, BE
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