TY - JOUR
T1 - The copper mediated Barbier reactions of α,β-unsaturated ketones
T2 - Regioselective conjugate and 1,2-addition
AU - Costello, Declan P.
AU - Geraghty, Niall W.A.
PY - 1999
Y1 - 1999
N2 - The one-pot reaction of isophorone and other α,β-unsaturated ketones with alkyl and aryl halides in the presence of magnesium and a copper salt ('Barbier' conditions) leads to the regiospecific formation of 1,4-addition products; the use of lithium leads to regioselective 1,2-addition.
AB - The one-pot reaction of isophorone and other α,β-unsaturated ketones with alkyl and aryl halides in the presence of magnesium and a copper salt ('Barbier' conditions) leads to the regiospecific formation of 1,4-addition products; the use of lithium leads to regioselective 1,2-addition.
UR - http://www.scopus.com/inward/record.url?scp=0032786762&partnerID=8YFLogxK
U2 - 10.1080/00397919908085932
DO - 10.1080/00397919908085932
M3 - Article
AN - SCOPUS:0032786762
SN - 0039-7911
VL - 29
SP - 3083
EP - 3096
JO - Synthetic Communications
JF - Synthetic Communications
IS - 18
ER -