The clinical features of the overlap between COPD and asthma

COPDGene Investigators

doi:10.1186/1465-9921-12-127

The clinical features of the overlap between COPD and asthma

COPDGene Investigators

Mathematics

Channing Laboratory
Harvard Medical School
Columbia University
The Johns Hopkins University School of Medicine
National Jewish Health
Brigham and Women's Hospital
Baylor College of Medicine
Columbia University
Duke University Medical Center
Fallon Clinic
HealthPartners Research Foundation
Johns Hopkins University
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Methodist DeBakey Heart and Vascular Center
Morehouse School of Medicine
Temple University
University of Alabama at Birmingham
University of California San Diego
University of Iowa
University of Michigan, Ann Arbor
University of Minnesota Twin Cities
University of Pittsburgh
University of Texas Health Science Center at San Antonio
LDS Hospital
University of Colorado School of Public Health

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

397 Citations (Scopus)

Abstract

Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

Original language	English
Article number	127
Journal	Respiratory Research
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1465-9921-12-127
Publication status	Published - 27 Sep 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Airway hyperresponsiveness
Asthma
Chronic obstructive pulmonary disease
Emphysema
Exacerbation
Gas-trapping

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10.1186/1465-9921-12-127

Cite this

@article{64ca4d4e5c014bbc944f97edf12f49f9,

title = "The clinical features of the overlap between COPD and asthma",

abstract = "Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13\%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6\% vs 15.6\%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.",

keywords = "Airway hyperresponsiveness, Asthma, Chronic obstructive pulmonary disease, Emphysema, Exacerbation, Gas-trapping",

author = "\{COPDGene Investigators\} and Megan Hardin and Silverman, \{Edwin K.\} and Barr, \{R. Graham\} and Hansel, \{Nadia N.\} and Schroeder, \{Joyce D.\} and Make, \{Barry J.\} and Crapo, \{James D.\} and Hersh, \{Craig P.\} and Jeffrey Curtis and Ella Kazerooni and Nicola Hanania and Philip Alapat and Venkata Bandi and Kalpalatha Guntupalli and Elizabeth Guy and Antara Mallampalli and Charles Trinh and Mustafa Atik and Dawn DeMeo and George Washko and Francine Jacobson and \{Graham Barr\}, R. and Byron Thomashow and John Austin and \{Neil MacIntyre\}, MacIntyre and Lacey Washington and \{Page McAdams\}, H. and Richard Rosiello and Timothy Bresnahan and Charlene McEvoy and Joseph Tashjian and Robert Wise and Nadia Hansel and Robert Brown and Gregory Diette and Richard Casaburi and Janos Porszasz and Hans Fischer and Matt Budoff and Amir Sharafkhaneh and Charles Trinh and Hirani Kamal and Roham Darvishi and Dennis Niewoehner and Tadashi Allen and Quentin Anderson and Kathryn Rice and Marilyn Foreman and Gloria Westney and Eugene Berkowitz and Russell Bowler and Adam Friedlander and David Lynch and Joyce Schroeder and John Newell and Gerard Criner and Victor Kim and Nathaniel Marchetti and Aditi Satti and \{James Mamary\}, A. and Robert Steiner and Chandra Dass and William Bailey and Mark Dransfield and Hrudaya Nath and Joe Ramsdell and Paul Friedman and Geoffrey McLennan and \{van Beek\}, \{Edwin J.R.\} and Brad Thompson and Dwight Look and Fernando Martinez and Han, \{Mei Lan\} and Ella Kazerooni and Christine Wendt and Tadashi Allen and Frank Sciurba and Joel Weissfeld and Carl Fuhrman and Jessica Bon and Antonio Anzueto and Sandra Adams and Carlos Orozco and Mario Ruiz and Robert Jensen and Homayoon Farzadegan and Stacey Meyerer and Shivam Chandan and Samantha Bragan and James Murphy and Douglas Everett and Ruthie Knowles and Amber Powell and John Hokanson and \{Jennifer Black-Shinn\}, Black-Shinn and Gregory Kinney and James Crapo and Edwin Silverman and Barry Make and John Newell",

note = "Publisher Copyright: {\textcopyright} 2011 Hardin et al; licensee BioMed Central Ltd.",

year = "2011",

month = sep,

day = "27",

doi = "10.1186/1465-9921-12-127",

language = "English",

volume = "12",

journal = "Respiratory Research",

issn = "1465-9921",

publisher = "BioMed Central Ltd",

number = "1",

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TY - JOUR

T1 - The clinical features of the overlap between COPD and asthma

AU - COPDGene Investigators

AU - Hardin, Megan

AU - Silverman, Edwin K.

AU - Barr, R. Graham

AU - Hansel, Nadia N.

AU - Schroeder, Joyce D.

AU - Make, Barry J.

AU - Crapo, James D.

AU - Hersh, Craig P.

AU - Curtis, Jeffrey

AU - Kazerooni, Ella

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Bandi, Venkata

AU - Guntupalli, Kalpalatha

AU - Guy, Elizabeth

AU - Mallampalli, Antara

AU - Trinh, Charles

AU - Atik, Mustafa

AU - DeMeo, Dawn

AU - Washko, George

AU - Jacobson, Francine

AU - Graham Barr, R.

AU - Thomashow, Byron

AU - Austin, John

AU - Neil MacIntyre, MacIntyre

AU - Washington, Lacey

AU - Page McAdams, H.

AU - Rosiello, Richard

AU - Bresnahan, Timothy

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert

AU - Hansel, Nadia

AU - Brown, Robert

AU - Diette, Gregory

AU - Casaburi, Richard

AU - Porszasz, Janos

AU - Fischer, Hans

AU - Budoff, Matt

AU - Sharafkhaneh, Amir

AU - Trinh, Charles

AU - Kamal, Hirani

AU - Darvishi, Roham

AU - Niewoehner, Dennis

AU - Allen, Tadashi

AU - Anderson, Quentin

AU - Rice, Kathryn

AU - Foreman, Marilyn

AU - Westney, Gloria

AU - Berkowitz, Eugene

AU - Bowler, Russell

AU - Friedlander, Adam

AU - Lynch, David

AU - Schroeder, Joyce

AU - Newell, John

AU - Criner, Gerard

AU - Kim, Victor

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - James Mamary, A.

AU - Steiner, Robert

AU - Dass, Chandra

AU - Bailey, William

AU - Dransfield, Mark

AU - Nath, Hrudaya

AU - Ramsdell, Joe

AU - Friedman, Paul

AU - McLennan, Geoffrey

AU - van Beek, Edwin J.R.

AU - Thompson, Brad

AU - Look, Dwight

AU - Martinez, Fernando

AU - Han, Mei Lan

AU - Kazerooni, Ella

AU - Wendt, Christine

AU - Allen, Tadashi

AU - Sciurba, Frank

AU - Weissfeld, Joel

AU - Fuhrman, Carl

AU - Bon, Jessica

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Orozco, Carlos

AU - Ruiz, Mario

AU - Jensen, Robert

AU - Farzadegan, Homayoon

AU - Meyerer, Stacey

AU - Chandan, Shivam

AU - Bragan, Samantha

AU - Murphy, James

AU - Everett, Douglas

AU - Knowles, Ruthie

AU - Powell, Amber

AU - Hokanson, John

AU - Jennifer Black-Shinn, Black-Shinn

AU - Kinney, Gregory

AU - Crapo, James

AU - Silverman, Edwin

AU - Make, Barry

AU - Newell, John

PY - 2011/9/27

Y1 - 2011/9/27

N2 - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

AB - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

KW - Airway hyperresponsiveness

KW - Asthma

KW - Chronic obstructive pulmonary disease

KW - Emphysema

KW - Exacerbation

KW - Gas-trapping

UR - https://www.scopus.com/pages/publications/80053346631

U2 - 10.1186/1465-9921-12-127

DO - 10.1186/1465-9921-12-127

M3 - Article

C2 - 21951550

AN - SCOPUS:80053346631

SN - 1465-9921

VL - 12

JO - Respiratory Research

JF - Respiratory Research

IS - 1

M1 - 127

ER -

The clinical features of the overlap between COPD and asthma

Abstract

UN SDGs

Keywords

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