@inbook{fc04834545ca48c5ab24f41952eed0bd,
title = "The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola",
abstract = "Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.",
keywords = "Cathepsin, Cysteine peptidase, Enzymes, Fasciola, Food-borne, Genomics, Helminths, Phylogenetics, Protein structure, Proteinase, Proteomics, Transcriptomics, Trematode, Trematodes",
author = "Krystyna Cwiklinski and Sheila Donnelly and Orla Drysdale and Heather Jewhurst and David Smith and \{De Marco Verissimo\}, Carolina and Pritsch, \{Izanara C.\} and Sandra O'Neill and Dalton, \{John P.\} and Robinson, \{Mark W.\}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
doi = "10.1016/bs.apar.2019.01.001",
language = "English",
isbn = "9780128177167",
series = "Advances in Parasitology",
publisher = "Academic Press",
pages = "113--164",
editor = "D. Rollinson and J.R. Stothard",
booktitle = "Advances in Parasitology",
}