Targeting novel signaling pathways for resistant acute myeloid leukemia

Kathleen M. Sakamoto; Steven Grant; Diana Saleiro; John D. Crispino; Nobuko Hijiya; Francis Giles; Leonidas Platanias; Elizabeth A. Eklund

doi:10.1016/j.ymgme.2014.11.017

Targeting novel signaling pathways for resistant acute myeloid leukemia

Kathleen M. Sakamoto
, Steven Grant
, Diana Saleiro
, John D. Crispino
, Nobuko Hijiya
, Francis Giles
, Leonidas Platanias
, Elizabeth A. Eklund

Stanford University School of Medicine
Virginia Commonwealth University
Northwestern University Feinberg School of Medicine
Jesse Brown VA Medical Center

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

64 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML.

Original language	English
Pages (from-to)	397-402
Number of pages	6
Journal	Molecular Genetics and Metabolism
Volume	114
Issue number	3
DOIs	https://doi.org/10.1016/j.ymgme.2014.11.017
Publication status	Published - 1 Mar 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myeloid leukemia
Novel therapies
Resistance
Signaling pathways

Access to Document

10.1016/j.ymgme.2014.11.017

Cite this

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title = "Targeting novel signaling pathways for resistant acute myeloid leukemia",

abstract = "Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML.",

keywords = "Acute myeloid leukemia, Novel therapies, Resistance, Signaling pathways",

author = "Sakamoto, \{Kathleen M.\} and Steven Grant and Diana Saleiro and Crispino, \{John D.\} and Nobuko Hijiya and Francis Giles and Leonidas Platanias and Eklund, \{Elizabeth A.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2015",

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day = "1",

doi = "10.1016/j.ymgme.2014.11.017",

language = "English",

volume = "114",

pages = "397--402",

journal = "Molecular Genetics and Metabolism",

issn = "1096-7192",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Targeting novel signaling pathways for resistant acute myeloid leukemia

AU - Sakamoto, Kathleen M.

AU - Grant, Steven

AU - Saleiro, Diana

AU - Crispino, John D.

AU - Hijiya, Nobuko

AU - Giles, Francis

AU - Platanias, Leonidas

AU - Eklund, Elizabeth A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML.

AB - Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML.

KW - Acute myeloid leukemia

KW - Novel therapies

KW - Resistance

KW - Signaling pathways

UR - https://www.scopus.com/pages/publications/84924122265

U2 - 10.1016/j.ymgme.2014.11.017

DO - 10.1016/j.ymgme.2014.11.017

M3 - Review article

C2 - 25533111

AN - SCOPUS:84924122265

SN - 1096-7192

VL - 114

SP - 397

EP - 402

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 3

ER -

Targeting novel signaling pathways for resistant acute myeloid leukemia

Abstract

UN SDGs

Keywords

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