Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Linda Foit; Francis J. Giles; Leo I. Gordon; Colby Shad Thaxton

doi:10.1586/14737140.2015.990889

Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Linda Foit
, Francis J. Giles
, Leo I. Gordon
, Colby Shad Thaxton

Northwestern University Feinberg School of Medicine
Institute for BioNanotechnology and Medicine (IBNAM)
Northwestern University
International Institute for Nanotechnology

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

25 Citations (Scopus)

Abstract

High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

Original language	English
Pages (from-to)	27-34
Number of pages	8
Journal	Expert Review of Anticancer Therapy
Volume	15
Issue number	1
DOIs	https://doi.org/10.1586/14737140.2015.990889
Publication status	Published - 1 Jan 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
cholesterol
drug delivery
high-density lipoprotein
nucleic acids
scavenger receptor

Access to Document

10.1586/14737140.2015.990889

Cite this

@article{eb7a1d3148694f598b24791bf49e266f,

title = "Synthetic high-density lipoprotein-like nanoparticles for cancer therapy",

abstract = "High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.",

keywords = "cancer, cholesterol, drug delivery, high-density lipoprotein, nucleic acids, scavenger receptor",

author = "Linda Foit and Giles, \{Francis J.\} and Gordon, \{Leo I.\} and Thaxton, \{Colby Shad\}",

note = "Publisher Copyright: {\textcopyright} 2015 Informa UK Ltd.",

year = "2014",

month = jan,

day = "1",

doi = "10.1586/14737140.2015.990889",

language = "English",

volume = "15",

pages = "27--34",

journal = "Expert Review of Anticancer Therapy",

issn = "1473-7140",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

AU - Foit, Linda

AU - Giles, Francis J.

AU - Gordon, Leo I.

AU - Thaxton, Colby Shad

PY - 2014/1/1

Y1 - 2014/1/1

N2 - High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

AB - High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

KW - cancer

KW - cholesterol

KW - drug delivery

KW - high-density lipoprotein

KW - nucleic acids

KW - scavenger receptor

UR - https://www.scopus.com/pages/publications/84919783401

U2 - 10.1586/14737140.2015.990889

DO - 10.1586/14737140.2015.990889

M3 - Article

C2 - 25487833

AN - SCOPUS:84919783401

SN - 1473-7140

VL - 15

SP - 27

EP - 34

JO - Expert Review of Anticancer Therapy

JF - Expert Review of Anticancer Therapy

IS - 1

ER -

Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this