Synthesis of a benzomacrolactone-based somatostatin mimetic

Jian Zhou; Marie Christine Matos; Paul V. Murphy

doi:10.1021/ol202528k

Synthesis of a benzomacrolactone-based somatostatin mimetic

Jian Zhou
, Marie Christine Matos
, Paul V. Murphy

Infectious Disease

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

14 Citations (Scopus)

Abstract

The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from d-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).

Original language	English
Pages (from-to)	5716-5719
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	21
DOIs	https://doi.org/10.1021/ol202528k
Publication status	Published - 4 Nov 2011

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10.1021/ol202528k

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@article{e4553932ad294856b72df9305dc05ff5,

title = "Synthesis of a benzomacrolactone-based somatostatin mimetic",

abstract = "The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from d-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).",

author = "Jian Zhou and Matos, \{Marie Christine\} and Murphy, \{Paul V.\}",

year = "2011",

month = nov,

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doi = "10.1021/ol202528k",

language = "English",

volume = "13",

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journal = "Organic Letters",

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T1 - Synthesis of a benzomacrolactone-based somatostatin mimetic

AU - Zhou, Jian

AU - Matos, Marie Christine

AU - Murphy, Paul V.

PY - 2011/11/4

Y1 - 2011/11/4

N2 - The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from d-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).

AB - The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from d-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).

UR - https://www.scopus.com/pages/publications/80055072366

U2 - 10.1021/ol202528k

DO - 10.1021/ol202528k

M3 - Article

SN - 1523-7060

VL - 13

SP - 5716

EP - 5719

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Synthesis of a benzomacrolactone-based somatostatin mimetic

Abstract

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