Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions

Colin O. Brien; Paul V. Murphy

doi:10.1080/07328303.2011.619287

Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions

Colin O. Brien
, Paul V. Murphy

Infectious Disease

University College Dublin

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

7 Citations (Scopus)

Abstract

A strategy for the synthesis of 1-deoxynojirimycin (DNJ) derivatives from L-sorbose is described. The sequence involved eight steps and afforded DNJ derivatives in 13% to 44% overall yield.

Original language	English
Pages (from-to)	626-640
Number of pages	15
Journal	Journal of Carbohydrate Chemistry
Volume	30
Issue number	7-9
DOIs	https://doi.org/10.1080/07328303.2011.619287
Publication status	Published - 1 Sep 2011

Keywords

1-Deoxynojirimycin
Lactol
Wittig reactions

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10.1080/07328303.2011.619287

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title = "Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions",

abstract = "A strategy for the synthesis of 1-deoxynojirimycin (DNJ) derivatives from L-sorbose is described. The sequence involved eight steps and afforded DNJ derivatives in 13\% to 44\% overall yield.",

keywords = "1-Deoxynojirimycin, Lactol, Wittig reactions",

author = "Brien, \{Colin O.\} and Murphy, \{Paul V.\}",

year = "2011",

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doi = "10.1080/07328303.2011.619287",

language = "English",

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journal = "Journal of Carbohydrate Chemistry",

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T1 - Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions

AU - Brien, Colin O.

AU - Murphy, Paul V.

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Y1 - 2011/9/1

N2 - A strategy for the synthesis of 1-deoxynojirimycin (DNJ) derivatives from L-sorbose is described. The sequence involved eight steps and afforded DNJ derivatives in 13% to 44% overall yield.

AB - A strategy for the synthesis of 1-deoxynojirimycin (DNJ) derivatives from L-sorbose is described. The sequence involved eight steps and afforded DNJ derivatives in 13% to 44% overall yield.

KW - 1-Deoxynojirimycin

KW - Lactol

KW - Wittig reactions

UR - https://www.scopus.com/pages/publications/84856356172

U2 - 10.1080/07328303.2011.619287

DO - 10.1080/07328303.2011.619287

M3 - Article

AN - SCOPUS:84856356172

SN - 0732-8303

VL - 30

SP - 626

EP - 640

JO - Journal of Carbohydrate Chemistry

JF - Journal of Carbohydrate Chemistry

IS - 7-9

ER -

Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions

Abstract

Keywords

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