Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes

Joan J. Soldevila-Barreda; Andrea Pettenuzzo; Maria Azmanova; Laia Rafols; Amr A.A. Attia; Alexandru Lupan; Luca Ronconi; Nicolas P.E. Barry; Anaïs Pitto-Barry

doi:10.1002/hlca.202300064

Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes

Joan J. Soldevila-Barreda, Andrea Pettenuzzo, Maria Azmanova, Laia Rafols, Amr A.A. Attia, Alexandru Lupan, Luca Ronconi, Nicolas P.E. Barry, Anaïs Pitto-Barry

Infectious Disease

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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Abstract

The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.

Original language	English
Article number	e202300064
Journal	Helvetica Chimica Acta
Volume	106
Issue number	8
DOIs	https://doi.org/10.1002/hlca.202300064
Publication status	Published - Aug 2023

Keywords

cytotoxicity
glycoconjugates
half-sandwich metal complexes
sandwich complexes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hlca.202300064

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Soldevila-Barreda, J. J., Pettenuzzo, A., Azmanova, M., Rafols, L., Attia, A. A. A., Lupan, A., Ronconi, L., Barry, N. P. E., & Pitto-Barry, A. (2023). Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes. Helvetica Chimica Acta, 106(8), Article e202300064. https://doi.org/10.1002/hlca.202300064

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title = "Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes",

abstract = "The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors{\textquoteright} in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.",

keywords = "cytotoxicity, glycoconjugates, half-sandwich metal complexes, sandwich complexes",

author = "Soldevila-Barreda, {Joan J.} and Andrea Pettenuzzo and Maria Azmanova and Laia Rafols and Attia, {Amr A.A.} and Alexandru Lupan and Luca Ronconi and Barry, {Nicolas P.E.} and Ana{\"i}s Pitto-Barry",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Helvetica Chimica Acta published by Wiley-VHCA AG, Zurich, Switzerland.",

year = "2023",

month = aug,

doi = "10.1002/hlca.202300064",

language = "English",

volume = "106",

journal = "Helvetica Chimica Acta",

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TY - JOUR

T1 - Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes

AU - Soldevila-Barreda, Joan J.

AU - Pettenuzzo, Andrea

AU - Azmanova, Maria

AU - Rafols, Laia

AU - Attia, Amr A.A.

AU - Lupan, Alexandru

AU - Ronconi, Luca

AU - Barry, Nicolas P.E.

AU - Pitto-Barry, Anaïs

PY - 2023/8

Y1 - 2023/8

N2 - The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.

AB - The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.

KW - cytotoxicity

KW - glycoconjugates

KW - half-sandwich metal complexes

KW - sandwich complexes

UR - http://www.scopus.com/inward/record.url?scp=85166252709&partnerID=8YFLogxK

U2 - 10.1002/hlca.202300064

DO - 10.1002/hlca.202300064

M3 - Article

SN - 0018-019X

VL - 106

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 8

M1 - e202300064

ER -

Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes

Abstract

Keywords

UN SDGs

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