Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety

Václav Šícha; Pau Farràs; Bohumil Štíbr; Francesc Teixidor; Bohumír Grüner; Clara Viñas

doi:10.13025/14854

Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety

Václav Šícha
, Pau Farràs
, Bohumil Štíbr
, Francesc Teixidor
, Bohumír Grüner
, Clara Viñas

Institute of Inorganic Chemistry of the Czech Academy of Sciences
Campus de la U.A.B.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

17 Citations (Scopus)

Abstract

The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with [3,3′-Co-8-(CH₂CH₂O)₂- (1,2-C₂B₉H₁₀)-(1′,2′-C₂B ₉H₁₁)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a series of orange double-cluster mono and dianions. These were characterized by NMR and MS methods as [1′′-X-1′′,2′′-closo- C₂B₁₀H₁₁]^-, [2]^-; [1′′-X-1′′,7′′-closo-C₂ B₁₀H₁₁]^-, [3]^- and [1′′-X-1′′,12′′-closo-C₂B ₁₀H₁₁], [4]^- for the monoanions, whereas [1′′,2′′-X₂-1′′,2′ ′-closo-C₂B₁₀H₁₀]^2-, [2]^2-; [1′′,7′′-X₂-1′′,7′ ′-closo-C₂B₁₀H₁₀]^2-, [3]^2-; and [1′′,12′′-X₂-1′′, 12′′-closo-C₂B₁₀H₁₀]^2-, [4]^2- for the dianions (where X = 3,3′-Co-8-(CH₂CH₂O)₂- (1,2-C₂B₉H₁₀)-1′,2′-(C₂ B₉H₁₁)). Moreover, these borane-cage subunits can be easily modified via attaching variable substituents onto cage carbon and boron vertices, which makes these compounds structurally flexible potential candidates for BNCT of cancer and HIV-PR inhibition.

Original language	English
Pages (from-to)	1599-1601
Number of pages	3
Journal	Journal of Organometallic Chemistry
Volume	694
Issue number	11
DOIs	https://doi.org/10.13025/14854 https://doi.org/10.1016/j.jorganchem.2008.10.059
Publication status	Published - 1 May 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BNCT
Carborane
Metallacarborane
Polyanion
Ring-opening

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J Organometallic Chem 2009 SynthesisAccepted author manuscript, 170 KBLicence: CC BY-NC-ND

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title = "Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety",

abstract = "The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with [3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-(1′,2′-C2B 9H11)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a series of orange double-cluster mono and dianions. These were characterized by NMR and MS methods as [1′′-X-1′′,2′′-closo- C2B10H11]-, [2]-; [1′′-X-1′′,7′′-closo-C2 B10H11]-, [3]- and [1′′-X-1′′,12′′-closo-C2B 10H11], [4]- for the monoanions, whereas [1′′,2′′-X2-1′′,2′ ′-closo-C2B10H10]2-, [2]2-; [1′′,7′′-X2-1′′,7′ ′-closo-C2B10H10]2-, [3]2-; and [1′′,12′′-X2-1′′, 12′′-closo-C2B10H10]2-, [4]2- for the dianions (where X = 3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-1′,2′-(C2 B9H11)). Moreover, these borane-cage subunits can be easily modified via attaching variable substituents onto cage carbon and boron vertices, which makes these compounds structurally flexible potential candidates for BNCT of cancer and HIV-PR inhibition.",

keywords = "BNCT, Carborane, Metallacarborane, Polyanion, Ring-opening",

author = "V{\'a}clav {\v S}{\'i}cha and Pau Farr{\`a}s and Bohumil {\v S}t{\'i}br and Francesc Teixidor and Bohum{\'i}r Gr{\"u}ner and Clara Vi{\~n}as",

year = "2009",

month = may,

day = "1",

doi = "10.13025/14854",

language = "English",

volume = "694",

pages = "1599--1601",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

number = "11",

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TY - JOUR

T1 - Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety

AU - Šícha, Václav

AU - Farràs, Pau

AU - Štíbr, Bohumil

AU - Teixidor, Francesc

AU - Grüner, Bohumír

AU - Viñas, Clara

PY - 2009/5/1

Y1 - 2009/5/1

N2 - The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with [3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-(1′,2′-C2B 9H11)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a series of orange double-cluster mono and dianions. These were characterized by NMR and MS methods as [1′′-X-1′′,2′′-closo- C2B10H11]-, [2]-; [1′′-X-1′′,7′′-closo-C2 B10H11]-, [3]- and [1′′-X-1′′,12′′-closo-C2B 10H11], [4]- for the monoanions, whereas [1′′,2′′-X2-1′′,2′ ′-closo-C2B10H10]2-, [2]2-; [1′′,7′′-X2-1′′,7′ ′-closo-C2B10H10]2-, [3]2-; and [1′′,12′′-X2-1′′, 12′′-closo-C2B10H10]2-, [4]2- for the dianions (where X = 3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-1′,2′-(C2 B9H11)). Moreover, these borane-cage subunits can be easily modified via attaching variable substituents onto cage carbon and boron vertices, which makes these compounds structurally flexible potential candidates for BNCT of cancer and HIV-PR inhibition.

AB - The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with [3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-(1′,2′-C2B 9H11)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a series of orange double-cluster mono and dianions. These were characterized by NMR and MS methods as [1′′-X-1′′,2′′-closo- C2B10H11]-, [2]-; [1′′-X-1′′,7′′-closo-C2 B10H11]-, [3]- and [1′′-X-1′′,12′′-closo-C2B 10H11], [4]- for the monoanions, whereas [1′′,2′′-X2-1′′,2′ ′-closo-C2B10H10]2-, [2]2-; [1′′,7′′-X2-1′′,7′ ′-closo-C2B10H10]2-, [3]2-; and [1′′,12′′-X2-1′′, 12′′-closo-C2B10H10]2-, [4]2- for the dianions (where X = 3,3′-Co-8-(CH2CH2O)2- (1,2-C2B9H10)-1′,2′-(C2 B9H11)). Moreover, these borane-cage subunits can be easily modified via attaching variable substituents onto cage carbon and boron vertices, which makes these compounds structurally flexible potential candidates for BNCT of cancer and HIV-PR inhibition.

KW - BNCT

KW - Carborane

KW - Metallacarborane

KW - Polyanion

KW - Ring-opening

UR - http://hdl.handle.net/10379/5969

UR - https://www.scopus.com/pages/publications/63549118344

U2 - 10.13025/14854

DO - 10.13025/14854

M3 - Article

SN - 0022-328X

VL - 694

SP - 1599

EP - 1601

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 11

ER -

Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety

Abstract

UN SDGs

Keywords

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