Supramolecular Chemistry: An Enabling Tool for Asymmetric Catalysis

Asymmetric synthesis and supramolecular chemistry are cornerstones of modern organic chemistry. The combination of both fields to develop new approaches to enantioselective catalysis has gained considerable momentum in recent years. Herein, we highlight some of the advantages offered by various supramolecular architectures over conventional chiral catalysts and reflect on obstacles that currently limit widespread use of supramolecular tools in asymmetric synthesis. 1 Introduction 2 Discussion 2.1 Macrocycles 2.2 Surfactants 2.3 Metal-Organic Cages and Frameworks 2.4 Covalent Organic Frameworks 2.5 DNA 2.6 Mechanically Interlocked Molecules 3 Summary and Outlook 2025. Thieme. All rights reserved.