Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)

Hiren Solanki; Carlos Angulo-Preckler; Kevin Calabro; Navdeep Kaur; Perrine Lasserre; Bastien Cautain; Mercedes de la Cruz; Fernando Reyes; Conxita Avila; Olivier P. Thomas

doi:10.1016/j.tetlet.2018.07.055

Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)

Hiren Solanki, Carlos Angulo-Preckler, Kevin Calabro, Navdeep Kaur, Perrine Lasserre, Bastien Cautain, Mercedes de la Cruz, Fernando Reyes, Conxita Avila, Olivier P. Thomas

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17 Citations (Scopus)

Abstract

Following ecological and chemical screenings, the Antarctic sponge Phorbas areolatus was chemically investigated for the first time. Three new suberitane derivatives named isosuberitenone B, 19-episuberitenone B, and isoxaspirosuberitenone were identified together with the known compounds suberitenones A and B, and oxaspirosuberitenone after a thorough inspection of their NMR data. These compounds were found to exhibit moderate cytotoxic activity and their presence in this sponge rules out their use as a chemotaxonomic marker for Suberites sponges.

Original language	English
Pages (from-to)	3353-3356
Number of pages	4
Journal	Tetrahedron Letters
Volume	59
Issue number	36
DOIs	https://doi.org/10.1016/j.tetlet.2018.07.055
Publication status	Published - 5 Sep 2018

Keywords

Antarctica
Cytotoxicity
Phorbas
Polar regions
Sesterterpene
Sponge

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10.1016/j.tetlet.2018.07.055

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title = "Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)",

abstract = "Following ecological and chemical screenings, the Antarctic sponge Phorbas areolatus was chemically investigated for the first time. Three new suberitane derivatives named isosuberitenone B, 19-episuberitenone B, and isoxaspirosuberitenone were identified together with the known compounds suberitenones A and B, and oxaspirosuberitenone after a thorough inspection of their NMR data. These compounds were found to exhibit moderate cytotoxic activity and their presence in this sponge rules out their use as a chemotaxonomic marker for Suberites sponges.",

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T1 - Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)

AU - Solanki, Hiren

AU - Angulo-Preckler, Carlos

AU - Calabro, Kevin

AU - Kaur, Navdeep

AU - Lasserre, Perrine

AU - Cautain, Bastien

AU - de la Cruz, Mercedes

AU - Reyes, Fernando

AU - Avila, Conxita

AU - Thomas, Olivier P.

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Following ecological and chemical screenings, the Antarctic sponge Phorbas areolatus was chemically investigated for the first time. Three new suberitane derivatives named isosuberitenone B, 19-episuberitenone B, and isoxaspirosuberitenone were identified together with the known compounds suberitenones A and B, and oxaspirosuberitenone after a thorough inspection of their NMR data. These compounds were found to exhibit moderate cytotoxic activity and their presence in this sponge rules out their use as a chemotaxonomic marker for Suberites sponges.

AB - Following ecological and chemical screenings, the Antarctic sponge Phorbas areolatus was chemically investigated for the first time. Three new suberitane derivatives named isosuberitenone B, 19-episuberitenone B, and isoxaspirosuberitenone were identified together with the known compounds suberitenones A and B, and oxaspirosuberitenone after a thorough inspection of their NMR data. These compounds were found to exhibit moderate cytotoxic activity and their presence in this sponge rules out their use as a chemotaxonomic marker for Suberites sponges.

KW - Antarctica

KW - Cytotoxicity

KW - Phorbas

KW - Polar regions

KW - Sesterterpene

KW - Sponge

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DO - 10.1016/j.tetlet.2018.07.055

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)

Abstract

Keywords

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