Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Paul V. Murphy; Julie L. O'Brien; Lorraine J. Gorey-Feret; Amos B. Smith

doi:10.1016/S0960-894X(02)00220-2

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Paul V. Murphy
, Julie L. O'Brien
, Lorraine J. Gorey-Feret
, Amos B. Smith

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

27 Citations (Scopus)

Abstract

A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC₅₀ values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

Original language	English
Pages (from-to)	1763-1766
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(02)00220-2
Publication status	Published - 8 Jul 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0960-894X(02)00220-2

Cite this

@article{06420f1587cd45dd8ccbae183a76ce17,

title = "Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds",

abstract = "A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.",

author = "Murphy, \{Paul V.\} and O'Brien, \{Julie L.\} and Gorey-Feret, \{Lorraine J.\} and Smith, \{Amos B.\}",

year = "2002",

month = jul,

day = "8",

doi = "10.1016/S0960-894X(02)00220-2",

language = "English",

volume = "12",

pages = "1763--1766",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

AU - Murphy, Paul V.

AU - O'Brien, Julie L.

AU - Gorey-Feret, Lorraine J.

AU - Smith, Amos B.

PY - 2002/7/8

Y1 - 2002/7/8

N2 - A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

AB - A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

UR - https://www.scopus.com/pages/publications/0037042775

U2 - 10.1016/S0960-894X(02)00220-2

DO - 10.1016/S0960-894X(02)00220-2

M3 - Article

C2 - 12067556

AN - SCOPUS:0037042775

SN - 0960-894X

VL - 12

SP - 1763

EP - 1766

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this