TY - JOUR
T1 - Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure
AU - Biagini, Elena
AU - Valgimigli, Marco
AU - Smits, Pieter C.
AU - Poldermans, Don
AU - Schinkel, Arend F.L.
AU - Rizzello, Vittoria
AU - Onderwater-, Emile E.M.
AU - Bountioukos, Manolis
AU - Serruys, Patrick W.
PY - 2006/10
Y1 - 2006/10
N2 - Background: There is experimental evidence that transplanting skeletal myoblasts (SM) into the post-infarction myocardial scar improves regional and global left ventricular (LV) function. Aims: To evaluate short- and long-term regional and global LV functional effects of percutaneously transplanted SM in patients with ischaemic heart failure. Methods and results: Ten patients (mean age 60 ± 10 years, 8 males) with dilated ischaemic cardiomyopathy underwent percutaneous injection of autologous myoblasts. Regional and global LV function was evaluated by 2-dimensional echocardiography and tissue Doppler imaging (TDI) at rest and during low-dose dobutamine infusion to assess contractile reserve. After a baseline examination, sequential follow-ups were performed at 1, 3, and 6 months and 1 year. NYHA functional class decreased from 2.7 ± 0.5 to 1.9 ± 0.5 (p < 0.01) at one year. LV function and volumes at rest remained unchanged while contractile reserve significantly improved during follow-up. At low-dose dobutamine infusion, the peak systolic velocity in the regions of myoblasts injection significantly increased at TDI examination (from 7.7 ± 2.1 to 8.6 ± 1.8 cm/s, p = 0.02); LV ejection fraction improved (from 40 ± 9% to 46 ± 8%, p < 0.0001) and end-systolic volumes decreased (from 56 ± 28 to 50 ± 25 ml/m2, p = 0.001) at 1 year. Conclusion: In patients with ischaemic heart failure, percutaneous injection of autologous myoblasts may improve regional and global LV systolic function during dobutamine infusion, at 1-year follow-up.
AB - Background: There is experimental evidence that transplanting skeletal myoblasts (SM) into the post-infarction myocardial scar improves regional and global left ventricular (LV) function. Aims: To evaluate short- and long-term regional and global LV functional effects of percutaneously transplanted SM in patients with ischaemic heart failure. Methods and results: Ten patients (mean age 60 ± 10 years, 8 males) with dilated ischaemic cardiomyopathy underwent percutaneous injection of autologous myoblasts. Regional and global LV function was evaluated by 2-dimensional echocardiography and tissue Doppler imaging (TDI) at rest and during low-dose dobutamine infusion to assess contractile reserve. After a baseline examination, sequential follow-ups were performed at 1, 3, and 6 months and 1 year. NYHA functional class decreased from 2.7 ± 0.5 to 1.9 ± 0.5 (p < 0.01) at one year. LV function and volumes at rest remained unchanged while contractile reserve significantly improved during follow-up. At low-dose dobutamine infusion, the peak systolic velocity in the regions of myoblasts injection significantly increased at TDI examination (from 7.7 ± 2.1 to 8.6 ± 1.8 cm/s, p = 0.02); LV ejection fraction improved (from 40 ± 9% to 46 ± 8%, p < 0.0001) and end-systolic volumes decreased (from 56 ± 28 to 50 ± 25 ml/m2, p = 0.001) at 1 year. Conclusion: In patients with ischaemic heart failure, percutaneous injection of autologous myoblasts may improve regional and global LV systolic function during dobutamine infusion, at 1-year follow-up.
KW - Cell transplantation
KW - LV function
KW - Myocardial infarction
KW - Stress echocardiography
KW - Tissue Doppler imaging
UR - https://www.scopus.com/pages/publications/33750217321
U2 - 10.1016/j.ejheart.2005.12.004
DO - 10.1016/j.ejheart.2005.12.004
M3 - Article
C2 - 16510308
AN - SCOPUS:33750217321
SN - 1388-9842
VL - 8
SP - 641
EP - 648
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
IS - 6
ER -
