Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Sachiko Kanaji; Yoko Tanaka; Yasuhisa Sakata; Kohei Takeshita; Kazuhiko Arima; Shoichiro Ohta; Elizabeth J. Hansell; Conor Caffrey; Jeremy C. Mottram; Jonathan Lowther; Sheila Donnelly; Colin Stack; Tomoko Kadowaki; Kenji Yamamoto; James H. McKerrow; John P. Dalton; Graham H. Coombs; Kenji Izuhara

doi:10.1016/j.febslet.2007.07.072

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Sachiko Kanaji, Yoko Tanaka, Yasuhisa Sakata, Kohei Takeshita, Kazuhiko Arima, Shoichiro Ohta, Elizabeth J. Hansell, Conor Caffrey, Jeremy C. Mottram, Jonathan Lowther, Sheila Donnelly, Colin Stack, Tomoko Kadowaki, Kenji Yamamoto, James H. McKerrow, John P. Dalton, Graham H. Coombs, Kenji Izuhara

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

19 Citations (Scopus)

Abstract

The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.

Original language	English
Pages (from-to)	4260-4264
Number of pages	5
Journal	FEBS Letters
Volume	581
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2007.07.072
Publication status	Published - 4 Sep 2007
Externally published	Yes

Keywords

Cysteine protease
Inhibitor
Interleukin-13
Interleukin-4
Parasite
Serpin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2007.07.072

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Kanaji, S., Tanaka, Y., Sakata, Y., Takeshita, K., Arima, K., Ohta, S., Hansell, E. J., Caffrey, C., Mottram, J. C., Lowther, J., Donnelly, S., Stack, C., Kadowaki, T., Yamamoto, K., McKerrow, J. H., Dalton, J. P., Coombs, G. H., & Izuhara, K. (2007). Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Letters, 581(22), 4260-4264. https://doi.org/10.1016/j.febslet.2007.07.072

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title = "Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases",

abstract = "The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.",

keywords = "Cysteine protease, Inhibitor, Interleukin-13, Interleukin-4, Parasite, Serpin",

author = "Sachiko Kanaji and Yoko Tanaka and Yasuhisa Sakata and Kohei Takeshita and Kazuhiko Arima and Shoichiro Ohta and Hansell, \{Elizabeth J.\} and Conor Caffrey and Mottram, \{Jeremy C.\} and Jonathan Lowther and Sheila Donnelly and Colin Stack and Tomoko Kadowaki and Kenji Yamamoto and McKerrow, \{James H.\} and Dalton, \{John P.\} and Coombs, \{Graham H.\} and Kenji Izuhara",

year = "2007",

month = sep,

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doi = "10.1016/j.febslet.2007.07.072",

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Kanaji, S, Tanaka, Y, Sakata, Y, Takeshita, K, Arima, K, Ohta, S, Hansell, EJ, Caffrey, C, Mottram, JC, Lowther, J, Donnelly, S, Stack, C, Kadowaki, T, Yamamoto, K, McKerrow, JH, Dalton, JP, Coombs, GH & Izuhara, K 2007, 'Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases', FEBS Letters, vol. 581, no. 22, pp. 4260-4264. https://doi.org/10.1016/j.febslet.2007.07.072

TY - JOUR

T1 - Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

AU - Kanaji, Sachiko

AU - Tanaka, Yoko

AU - Sakata, Yasuhisa

AU - Takeshita, Kohei

AU - Arima, Kazuhiko

AU - Ohta, Shoichiro

AU - Hansell, Elizabeth J.

AU - Caffrey, Conor

AU - Mottram, Jeremy C.

AU - Lowther, Jonathan

AU - Donnelly, Sheila

AU - Stack, Colin

AU - Kadowaki, Tomoko

AU - Yamamoto, Kenji

AU - McKerrow, James H.

AU - Dalton, John P.

AU - Coombs, Graham H.

AU - Izuhara, Kenji

PY - 2007/9/4

Y1 - 2007/9/4

N2 - The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.

AB - The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.

KW - Cysteine protease

KW - Inhibitor

KW - Interleukin-13

KW - Interleukin-4

KW - Parasite

KW - Serpin

UR - https://www.scopus.com/pages/publications/34548153043

U2 - 10.1016/j.febslet.2007.07.072

DO - 10.1016/j.febslet.2007.07.072

M3 - Article

SN - 0014-5793

VL - 581

SP - 4260

EP - 4264

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Abstract

Keywords

UN SDGs

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