Spontaneous cytotoxicity

Rhodri Ceredig

Spontaneous cytotoxicity

Rhodri Ceredig

Medicine

Royal Melbourne Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

When mouse spleen cells were cultured in vitro without the deliberate addition of any stimulating cells, T cell-mediated cytotoxicity was generated which could be detected by lysis of ⁵¹Cr-labelled syngeneic and allogeneic tumour target cells. The clonal basis of such spontaneous cytotoxicity was investigated by limit dilution analysis and a comparison made between it and so-called 'tumour-specific' cytotoxicity generated in vitro.

Original language	English (Ireland)
Pages (from-to)	681-694
Number of pages	14
Journal	Aust J Exp Biol Med Sci
Volume	59
Issue number	Pt 6Pt 6
Publication status	Published - 1 Dec 1981

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Ceredig, R.

Cite this

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title = "Spontaneous cytotoxicity",

abstract = "When mouse spleen cells were cultured in vitro without the deliberate addition of any stimulating cells, T cell-mediated cytotoxicity was generated which could be detected by lysis of 51Cr-labelled syngeneic and allogeneic tumour target cells. The clonal basis of such spontaneous cytotoxicity was investigated by limit dilution analysis and a comparison made between it and so-called 'tumour-specific' cytotoxicity generated in vitro.",

author = "Rhodri Ceredig",

year = "1981",

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language = "English (Ireland)",

volume = "59",

pages = "681--694",

journal = "Aust J Exp Biol Med Sci",

number = "Pt 6Pt 6",

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AU - Ceredig, Rhodri

PY - 1981/12/1

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N2 - When mouse spleen cells were cultured in vitro without the deliberate addition of any stimulating cells, T cell-mediated cytotoxicity was generated which could be detected by lysis of 51Cr-labelled syngeneic and allogeneic tumour target cells. The clonal basis of such spontaneous cytotoxicity was investigated by limit dilution analysis and a comparison made between it and so-called 'tumour-specific' cytotoxicity generated in vitro.

AB - When mouse spleen cells were cultured in vitro without the deliberate addition of any stimulating cells, T cell-mediated cytotoxicity was generated which could be detected by lysis of 51Cr-labelled syngeneic and allogeneic tumour target cells. The clonal basis of such spontaneous cytotoxicity was investigated by limit dilution analysis and a comparison made between it and so-called 'tumour-specific' cytotoxicity generated in vitro.

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M3 - Article

C2 - 6978707

AN - SCOPUS:0019724517

VL - 59

SP - 681

EP - 694

JO - Aust J Exp Biol Med Sci

JF - Aust J Exp Biol Med Sci

IS - Pt 6Pt 6

ER -

Spontaneous cytotoxicity

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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