Spinal cord injury in vitro: Modelling axon growth inhibition

Mohammad Abu-Rub; Siobhan S. McMahon; Dimitrios I. Zeugolis; Abhay Shashikant Pandit

doi:10.13025/21669

Spinal cord injury in vitro: Modelling axon growth inhibition

Mohammad Abu-Rub
, Siobhan S. McMahon
, Dimitrios I. Zeugolis
, Abhay Shashikant Pandit

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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Abstract

Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.

Original language	English (Ireland)
Number of pages	7
Journal	Drug Discovery Today
Volume	15
DOIs	https://doi.org/10.13025/21669
Publication status	Published - 1 Jan 2010

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10.13025/21669Licence: CC BY-NC-ND

Advanced Drug Delivery ReviewsAccepted author manuscript, 1.59 MBLicence: CC BY-NC-ND

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title = "Spinal cord injury in vitro: Modelling axon growth inhibition",

abstract = "Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.",

author = "Mohammad Abu-Rub and McMahon, \{Siobhan S.\} and Zeugolis, \{Dimitrios I.\} and Pandit, \{Abhay Shashikant\}",

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N2 - Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.

AB - Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.

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Spinal cord injury in vitro: Modelling axon growth inhibition

Abstract

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