Solo or doppio: How many CENP-As make a centromeric nucleosome?

Elaine M. Dunleavy; Weiguo Zhang; Gary H. Karpen

doi:10.1038/nsmb.2602

Solo or doppio: How many CENP-As make a centromeric nucleosome?

Elaine M. Dunleavy
, Weiguo Zhang
, Gary H. Karpen

Molecular Biosciences

Lawrence Berkeley National Laboratory
University of California Berkeley

Research output: Contribution to a Journal (Peer & Non Peer) › Short survey › peer-review

14 Citations (Scopus)

Abstract

Whether centromere-specific CENP-A-containing nucleosomes comprise one molecule each of CENP-A and histones H4, H2A and H2B (forming a tetramer or hemisome) or two molecules of all four histones (forming an octamer) has been controversial. Three new studies now address this controversy using complementary in vitro and in vivo approaches.

Original language	English
Pages (from-to)	648-650
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1038/nsmb.2602
Publication status	Published - Jun 2013

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10.1038/nsmb.2602

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title = "Solo or doppio: How many CENP-As make a centromeric nucleosome?",

abstract = "Whether centromere-specific CENP-A-containing nucleosomes comprise one molecule each of CENP-A and histones H4, H2A and H2B (forming a tetramer or hemisome) or two molecules of all four histones (forming an octamer) has been controversial. Three new studies now address this controversy using complementary in vitro and in vivo approaches.",

author = "Dunleavy, \{Elaine M.\} and Weiguo Zhang and Karpen, \{Gary H.\}",

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AU - Dunleavy, Elaine M.

AU - Zhang, Weiguo

AU - Karpen, Gary H.

PY - 2013/6

Y1 - 2013/6

N2 - Whether centromere-specific CENP-A-containing nucleosomes comprise one molecule each of CENP-A and histones H4, H2A and H2B (forming a tetramer or hemisome) or two molecules of all four histones (forming an octamer) has been controversial. Three new studies now address this controversy using complementary in vitro and in vivo approaches.

AB - Whether centromere-specific CENP-A-containing nucleosomes comprise one molecule each of CENP-A and histones H4, H2A and H2B (forming a tetramer or hemisome) or two molecules of all four histones (forming an octamer) has been controversial. Three new studies now address this controversy using complementary in vitro and in vivo approaches.

UR - https://www.scopus.com/pages/publications/84878918476

U2 - 10.1038/nsmb.2602

DO - 10.1038/nsmb.2602

M3 - Short survey

SN - 1545-9993

VL - 20

SP - 648

EP - 650

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 6

ER -

Solo or doppio: How many CENP-As make a centromeric nucleosome?

Abstract

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