Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro

Michele Carbone; Janet Hauser; Michael P. Carty; Kathleen Rundell; Kathleen Dixon; Arthur S. Levine

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro

Michele Carbone
, Janet Hauser
, Michael P. Carty
, Kathleen Rundell
, Kathleen Dixon
, Arthur S. Levine

National Institute of Child Health and Human Development (NICHD)
Northwestern University Feinberg School of Medicine
University of Cincinnati Medical Centre

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

13 Citations (Scopus)

Abstract

We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

Original language	English
Pages (from-to)	1804-1808
Number of pages	5
Journal	Journal of Virology
Volume	66
Issue number	3
Publication status	Published - Mar 1992
Externally published	Yes

Cite this

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title = "Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro",

abstract = "We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.",

author = "Michele Carbone and Janet Hauser and Carty, \{Michael P.\} and Kathleen Rundell and Kathleen Dixon and Levine, \{Arthur S.\}",

year = "1992",

month = mar,

language = "English",

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T1 - Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro

AU - Carbone, Michele

AU - Hauser, Janet

AU - Carty, Michael P.

AU - Rundell, Kathleen

AU - Dixon, Kathleen

AU - Levine, Arthur S.

PY - 1992/3

Y1 - 1992/3

N2 - We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

AB - We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

UR - https://www.scopus.com/pages/publications/0026576335

M3 - Article

C2 - 1310784

AN - SCOPUS:0026576335

SN - 0022-538X

VL - 66

SP - 1804

EP - 1808

JO - Journal of Virology

JF - Journal of Virology

IS - 3

ER -

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro

Abstract

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