Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum

Risoleta Ortet; Soizic Prado; Elisabeth Mouray; Olivier P. Thomas

doi:10.1016/j.phytochem.2008.09.022

Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum

Risoleta Ortet, Soizic Prado, Elisabeth Mouray, Olivier P. Thomas

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

55 Citations (Scopus)

Abstract

Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the ¹³C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC₅₀ of 3.8 ± 0.7 μg ml^-1 against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC₅₀ 71.0 ± 3.9 μg ml^-1).

Original language	English
Pages (from-to)	2961-2965
Number of pages	5
Journal	Phytochemistry
Volume	69
Issue number	17
DOIs	https://doi.org/10.1016/j.phytochem.2008.09.022
Publication status	Published - Dec 2008
Externally published	Yes

Keywords

Antimalarial
Artemisia
Asteraceae
Guaianolide
Sesquiterpene lactones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2008.09.022

Cite this

@article{d855806e15ee4392a7edae05efe57855,

title = "Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum",

abstract = "Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the 13C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC50 of 3.8 ± 0.7 μg ml-1 against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC50 71.0 ± 3.9 μg ml-1).",

keywords = "Antimalarial, Artemisia, Asteraceae, Guaianolide, Sesquiterpene lactones",

author = "Risoleta Ortet and Soizic Prado and Elisabeth Mouray and Thomas, \{Olivier P.\}",

year = "2008",

month = dec,

doi = "10.1016/j.phytochem.2008.09.022",

language = "English",

volume = "69",

pages = "2961--2965",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

number = "17",

}

TY - JOUR

T1 - Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum

AU - Ortet, Risoleta

AU - Prado, Soizic

AU - Mouray, Elisabeth

AU - Thomas, Olivier P.

PY - 2008/12

Y1 - 2008/12

N2 - Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the 13C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC50 of 3.8 ± 0.7 μg ml-1 against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC50 71.0 ± 3.9 μg ml-1).

AB - Leaves and flowers of Artemisia gorgonum (Asteraceae) collected in Fogo, Cape Verde islands, were phytochemically investigated and resulted in isolation and characterization of three guaianolides 1, 2, 5, and a secoguainolide 4, in addition to eight known guaianolides 6-11 and two known germacranolides 12, 13. Structures were elucidated by 1D and 2D NMR experiments. Careful examination of the 13C NMR spectrum led to revision of the structure of a previously described guaianolide from 2 to 3. Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC50 of 3.8 ± 0.7 μg ml-1 against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line (IC50 71.0 ± 3.9 μg ml-1).

KW - Antimalarial

KW - Artemisia

KW - Asteraceae

KW - Guaianolide

KW - Sesquiterpene lactones

UR - https://www.scopus.com/pages/publications/56249110581

U2 - 10.1016/j.phytochem.2008.09.022

DO - 10.1016/j.phytochem.2008.09.022

M3 - Article

C2 - 19007951

AN - SCOPUS:56249110581

SN - 0031-9422

VL - 69

SP - 2961

EP - 2965

JO - Phytochemistry

JF - Phytochemistry

IS - 17

ER -

Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum

Abstract

Keywords

UN SDGs

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