Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL

A. P. Jewell; K. L. Yong; C. P. Worman; C. P. Tsakona; F. J. Giles; A. H. Goldstone

doi:10.1111/j.1365-2141.1994.tb04766.x

Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL

A. P. Jewell, K. L. Yong, C. P. Worman, C. P. Tsakona, F. J. Giles, A. H. Goldstone

Kingston University

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

11 Citations (Scopus)

Abstract

Interferon-alpha (IFN-α) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-α therapy, peripheral lymphocyte counts fell to 61.7 ± 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 ± 183 U/ml to 686 ± 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-α in early-stage CLL.

Original language	English
Pages (from-to)	441-443
Number of pages	3
Journal	British Journal of Haematology
Volume	86
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.1994.tb04766.x
Publication status	Published - 1994
Externally published	Yes

Keywords

CLL
IFN-α
M-CSF
serum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2141.1994.tb04766.x

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title = "Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL",

abstract = "Interferon-alpha (IFN-α) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-α therapy, peripheral lymphocyte counts fell to 61.7 ± 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 ± 183 U/ml to 686 ± 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-α in early-stage CLL.",

keywords = "CLL, IFN-α, M-CSF, serum",

author = "Jewell, {A. P.} and Yong, {K. L.} and Worman, {C. P.} and Tsakona, {C. P.} and Giles, {F. J.} and Goldstone, {A. H.}",

year = "1994",

doi = "10.1111/j.1365-2141.1994.tb04766.x",

language = "English",

volume = "86",

pages = "441--443",

journal = "British Journal of Haematology",

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}

TY - JOUR

T1 - Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL

AU - Jewell, A. P.

AU - Yong, K. L.

AU - Worman, C. P.

AU - Tsakona, C. P.

AU - Giles, F. J.

AU - Goldstone, A. H.

PY - 1994

Y1 - 1994

N2 - Interferon-alpha (IFN-α) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-α therapy, peripheral lymphocyte counts fell to 61.7 ± 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 ± 183 U/ml to 686 ± 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-α in early-stage CLL.

AB - Interferon-alpha (IFN-α) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-α therapy, peripheral lymphocyte counts fell to 61.7 ± 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 ± 183 U/ml to 686 ± 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-α in early-stage CLL.

KW - CLL

KW - IFN-α

KW - M-CSF

KW - serum

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U2 - 10.1111/j.1365-2141.1994.tb04766.x

DO - 10.1111/j.1365-2141.1994.tb04766.x

M3 - Article

SN - 0007-1048

VL - 86

SP - 441

EP - 443

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL

Abstract

Keywords

UN SDGs

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