Sensing and responding to DNA damage

Noel F. Lowndes; Jose R. Murguia

doi:10.1016/S0959-437X(99)00050-7

Sensing and responding to DNA damage

Noel F. Lowndes
, Jose R. Murguia

Cancer Research UK

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

239 Citations (Scopus)

Abstract

DNA damage or stalled DNA replication can activate specific signal transduction pathways, termed checkpoints. Checkpoint activation can result in increased repair, induction of a transcriptional programme and inhibition of cell-cycle progression. Recent results have suggested possible mechanisms for the detection of specific DNA structures, provided further information on the organisation of the signal transduction cascade and demonstrated involvement of the checkpoint pathway in DNA repair.

Original language	English
Pages (from-to)	17-25
Number of pages	9
Journal	Current Opinion in Genetics and Development
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(99)00050-7
Publication status	Published - 1 Feb 2000
Externally published	Yes

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10.1016/S0959-437X(99)00050-7

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title = "Sensing and responding to DNA damage",

abstract = "DNA damage or stalled DNA replication can activate specific signal transduction pathways, termed checkpoints. Checkpoint activation can result in increased repair, induction of a transcriptional programme and inhibition of cell-cycle progression. Recent results have suggested possible mechanisms for the detection of specific DNA structures, provided further information on the organisation of the signal transduction cascade and demonstrated involvement of the checkpoint pathway in DNA repair.",

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AU - Murguia, Jose R.

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N2 - DNA damage or stalled DNA replication can activate specific signal transduction pathways, termed checkpoints. Checkpoint activation can result in increased repair, induction of a transcriptional programme and inhibition of cell-cycle progression. Recent results have suggested possible mechanisms for the detection of specific DNA structures, provided further information on the organisation of the signal transduction cascade and demonstrated involvement of the checkpoint pathway in DNA repair.

AB - DNA damage or stalled DNA replication can activate specific signal transduction pathways, termed checkpoints. Checkpoint activation can result in increased repair, induction of a transcriptional programme and inhibition of cell-cycle progression. Recent results have suggested possible mechanisms for the detection of specific DNA structures, provided further information on the organisation of the signal transduction cascade and demonstrated involvement of the checkpoint pathway in DNA repair.

UR - https://www.scopus.com/pages/publications/0034003395

U2 - 10.1016/S0959-437X(99)00050-7

DO - 10.1016/S0959-437X(99)00050-7

M3 - Review article

SN - 0959-437X

VL - 10

SP - 17

EP - 25

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 1

ER -

Sensing and responding to DNA damage

Abstract

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