Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma

Mihaela Onciu; Ellen Schlette; Yinmei Zhou; Susana C. Raimondi; Francis J. Giles; Hagop M. Kantarjian; L. Jeffrey Medeiros; Raul C. Ribeiro; Ching Hon Pui; John T. Sandlund

doi:10.1002/cncr.22089

Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma

Mihaela Onciu, Ellen Schlette, Yinmei Zhou, Susana C. Raimondi, Francis J. Giles, Hagop M. Kantarjian, L. Jeffrey Medeiros, Raul C. Ribeiro, Ching Hon Pui, John T. Sandlund

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

57 Citations (Scopus)

Abstract

BACKGROUND. Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact. METHODS. A retrospective analysis was performed in all pediatric and adult patients at 2 institutions, with a morphologic diagnosis of BL, pretherapy tumor karyotype available, and t(8;14), t(8;22), or t(2;8) present. RESULTS. There were 33 children and 37 adults. The majority of the patients (95%) had Stage III/IV disease. There were no statistically significant differences noted in karyotype complexity and the nature of the chromosomal abnormalities between these 2 groups. Abnormalities of chromosomes 13 (13q) and 22 (22q) had a negative impact on prognosis in children. In adults, abnormalities of chromosome 17 appeared to have a negative impact. CONCLUSIONS. The current findings suggest that karyotypic information can be used for refining risk stratification in patients with BL.

Original language	English
Pages (from-to)	1084-1092
Number of pages	9
Journal	Cancer
Volume	107
Issue number	5
DOIs	https://doi.org/10.1002/cncr.22089
Publication status	Published - 1 Sep 2006
Externally published	Yes

Keywords

Burkitt lymphoma
Chromosomes
Karyotype
Lymphoproliferative disorders
Neoplasia
Prognostication

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma",

abstract = "BACKGROUND. Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact. METHODS. A retrospective analysis was performed in all pediatric and adult patients at 2 institutions, with a morphologic diagnosis of BL, pretherapy tumor karyotype available, and t(8;14), t(8;22), or t(2;8) present. RESULTS. There were 33 children and 37 adults. The majority of the patients (95%) had Stage III/IV disease. There were no statistically significant differences noted in karyotype complexity and the nature of the chromosomal abnormalities between these 2 groups. Abnormalities of chromosomes 13 (13q) and 22 (22q) had a negative impact on prognosis in children. In adults, abnormalities of chromosome 17 appeared to have a negative impact. CONCLUSIONS. The current findings suggest that karyotypic information can be used for refining risk stratification in patients with BL.",

keywords = "Burkitt lymphoma, Chromosomes, Karyotype, Lymphoproliferative disorders, Neoplasia, Prognostication",

author = "Mihaela Onciu and Ellen Schlette and Yinmei Zhou and Raimondi, {Susana C.} and Giles, {Francis J.} and Kantarjian, {Hagop M.} and Medeiros, {L. Jeffrey} and Ribeiro, {Raul C.} and Pui, {Ching Hon} and Sandlund, {John T.}",

year = "2006",

month = sep,

day = "1",

doi = "10.1002/cncr.22089",

language = "English",

volume = "107",

pages = "1084--1092",

journal = "Cancer",

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TY - JOUR

T1 - Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma

AU - Onciu, Mihaela

AU - Schlette, Ellen

AU - Zhou, Yinmei

AU - Raimondi, Susana C.

AU - Giles, Francis J.

AU - Kantarjian, Hagop M.

AU - Medeiros, L. Jeffrey

AU - Ribeiro, Raul C.

AU - Pui, Ching Hon

AU - Sandlund, John T.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - BACKGROUND. Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact. METHODS. A retrospective analysis was performed in all pediatric and adult patients at 2 institutions, with a morphologic diagnosis of BL, pretherapy tumor karyotype available, and t(8;14), t(8;22), or t(2;8) present. RESULTS. There were 33 children and 37 adults. The majority of the patients (95%) had Stage III/IV disease. There were no statistically significant differences noted in karyotype complexity and the nature of the chromosomal abnormalities between these 2 groups. Abnormalities of chromosomes 13 (13q) and 22 (22q) had a negative impact on prognosis in children. In adults, abnormalities of chromosome 17 appeared to have a negative impact. CONCLUSIONS. The current findings suggest that karyotypic information can be used for refining risk stratification in patients with BL.

AB - BACKGROUND. Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact. METHODS. A retrospective analysis was performed in all pediatric and adult patients at 2 institutions, with a morphologic diagnosis of BL, pretherapy tumor karyotype available, and t(8;14), t(8;22), or t(2;8) present. RESULTS. There were 33 children and 37 adults. The majority of the patients (95%) had Stage III/IV disease. There were no statistically significant differences noted in karyotype complexity and the nature of the chromosomal abnormalities between these 2 groups. Abnormalities of chromosomes 13 (13q) and 22 (22q) had a negative impact on prognosis in children. In adults, abnormalities of chromosome 17 appeared to have a negative impact. CONCLUSIONS. The current findings suggest that karyotypic information can be used for refining risk stratification in patients with BL.

KW - Burkitt lymphoma

KW - Chromosomes

KW - Karyotype

KW - Lymphoproliferative disorders

KW - Neoplasia

KW - Prognostication

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DO - 10.1002/cncr.22089

M3 - Article

C2 - 16862570

AN - SCOPUS:33747893246

SN - 0008-543X

VL - 107

SP - 1084

EP - 1092

JO - Cancer

JF - Cancer

IS - 5

ER -

Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma

Abstract

Keywords

UN SDGs

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