TY - JOUR
T1 - Reproducible coronary plaque quantification by multislice computed tomography
AU - Bruining, Nico
AU - Roelandt, Jos R.T.C.
AU - Palumbo, Alessandro
AU - La Grutta, Ludovico
AU - Cademartiri, Filippo
AU - De Feijter, Pim J.
AU - Mollet, Nico
AU - Van Domburg, Ron T.
AU - Serruys, P. W.
AU - Hamers, Ronald
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Background: The aim of this study was to investigate reproducibility end accuracy of computer-assisted coronary plaque measurements by multislice computed tomography coronary angiography (QMSCT-CA). Methods and Results: Forty-sight patients undergoing MSCT-CA end coronary arteriography for symptomatic coronary artery disease and quantitative intravascular ultrasound (IVUS, QCU) were examined. Two investigators performed the QMSCT-CA twice end e third investigator performed the QCU, all blinded for each other's results. There was no difference found for the matched region of interest (ROI) lengths (QCU 29.4 ± 13 mm vs. QMSCT-CA 29.6 ± 13 mm, P = 0.6; total length = 1,400 mm). The comparison of volumetric measurements showed (lumen QCU 267 ± 139 mm3 vs. mean QMSCT-CA 177 ± 91 mm3, P < 0.001; vessel 454 ± 194 mm3 vs. 398 ± 187 mm 3, P < 0.001; and plaque 189 ± 93 mm3 vs. 222 ± 121 mm3; investigator 1, P = 0.02; and investigator 2, P = 0.07) significant differences. Automated lumen detection was also applied for QMSCT-CA (218 ± 112 mm3, P < 0.001 vs. QCU). The Interinvestigator variability measurements for QMSCT-CA showed no significant differences. Conclusion: QMSCT-CA systematically underestimates absolute coronary lumen- and vessel dimensions when compared with QCU. However, repeated measurements of coronary plaque by QMSCT-CA showed no statistically significant differences, although, the outcome showed a scattered result. Automated lumen detection for QMSCT-CA showed improved results when compered with those of human investigators.
AB - Background: The aim of this study was to investigate reproducibility end accuracy of computer-assisted coronary plaque measurements by multislice computed tomography coronary angiography (QMSCT-CA). Methods and Results: Forty-sight patients undergoing MSCT-CA end coronary arteriography for symptomatic coronary artery disease and quantitative intravascular ultrasound (IVUS, QCU) were examined. Two investigators performed the QMSCT-CA twice end e third investigator performed the QCU, all blinded for each other's results. There was no difference found for the matched region of interest (ROI) lengths (QCU 29.4 ± 13 mm vs. QMSCT-CA 29.6 ± 13 mm, P = 0.6; total length = 1,400 mm). The comparison of volumetric measurements showed (lumen QCU 267 ± 139 mm3 vs. mean QMSCT-CA 177 ± 91 mm3, P < 0.001; vessel 454 ± 194 mm3 vs. 398 ± 187 mm 3, P < 0.001; and plaque 189 ± 93 mm3 vs. 222 ± 121 mm3; investigator 1, P = 0.02; and investigator 2, P = 0.07) significant differences. Automated lumen detection was also applied for QMSCT-CA (218 ± 112 mm3, P < 0.001 vs. QCU). The Interinvestigator variability measurements for QMSCT-CA showed no significant differences. Conclusion: QMSCT-CA systematically underestimates absolute coronary lumen- and vessel dimensions when compared with QCU. However, repeated measurements of coronary plaque by QMSCT-CA showed no statistically significant differences, although, the outcome showed a scattered result. Automated lumen detection for QMSCT-CA showed improved results when compered with those of human investigators.
KW - Coronary artery disease
KW - Image processing
KW - Intravascular ultrasound
KW - Multislice computed tomography
UR - http://www.scopus.com/inward/record.url?scp=34249899444&partnerID=8YFLogxK
U2 - 10.1002/ccd.21067
DO - 10.1002/ccd.21067
M3 - Article
C2 - 17427207
AN - SCOPUS:34249899444
SN - 1522-1946
VL - 69
SP - 857
EP - 865
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
IS - 6
ER -
