Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes

Sanbing Shen; Sharon Battersby; Molly Weaver; Elma Clark; Karen Stephens; Anthony J. Harmar

doi:10.1038/sj.ejhg.5200400

Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes

Sanbing Shen, Sharon Battersby, Molly Weaver, Elma Clark, Karen Stephens, Anthony J. Harmar

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

16 Citations (Scopus)

Abstract

The SLC6A4 gene encodes the serotonin transporter, the target of an important class of antidepressant drugs (serotonin selective reuptake inhibitors). Polymorphisms in the SLC6A4 gene have been reported to be associated with susceptibility to depression and other psychiatric disorders. We have constructed a 1 Mb YAC and PAC contig which harbours both: the SLC6A4 and the carboxypeptidase D (CPD) genes. The order of loci within the contig was cen-D17S975-D17S1549-24R-D17S1294-SLC6A4-28L-(CPD, D17S2009, D17S2004)-D17S2120-ter. Both genes were deleted in one of 17 neurofibromatosis type 1 (NF1) patients carrying submicroscopic NF1 contiguous gene deletions..

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	European Journal of Human Genetics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/sj.ejhg.5200400
Publication status	Published - Jan 2000
Externally published	Yes

Keywords

CPD
NF1
Serotonin transporter
YAC contig

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10.1038/sj.ejhg.5200400

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abstract = "The SLC6A4 gene encodes the serotonin transporter, the target of an important class of antidepressant drugs (serotonin selective reuptake inhibitors). Polymorphisms in the SLC6A4 gene have been reported to be associated with susceptibility to depression and other psychiatric disorders. We have constructed a 1 Mb YAC and PAC contig which harbours both: the SLC6A4 and the carboxypeptidase D (CPD) genes. The order of loci within the contig was cen-D17S975-D17S1549-24R-D17S1294-SLC6A4-28L-(CPD, D17S2009, D17S2004)-D17S2120-ter. Both genes were deleted in one of 17 neurofibromatosis type 1 (NF1) patients carrying submicroscopic NF1 contiguous gene deletions..",

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AU - Shen, Sanbing

AU - Battersby, Sharon

AU - Weaver, Molly

AU - Clark, Elma

AU - Stephens, Karen

AU - Harmar, Anthony J.

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KW - CPD

KW - NF1

KW - Serotonin transporter

KW - YAC contig

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DO - 10.1038/sj.ejhg.5200400

M3 - Article

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Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes

Abstract

Keywords

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