Re-infection following sustained virological response with a different hepatitis C virus genotype: Implications for infection control policy

Michelle M. O'Shaughnessy; John A. O'Regan; Frank E. Murray; Jeff A. Connell; Margaret P. Duffy; Veronica M. Francis; Sharon Dwyer; Lelia M. Thornton; Peter J. Conlon

doi:10.1093/ckj/sfs040

Re-infection following sustained virological response with a different hepatitis C virus genotype: Implications for infection control policy

Michelle M. O'Shaughnessy, John A. O'Regan, Frank E. Murray, Jeff A. Connell, Margaret P. Duffy, Veronica M. Francis, Sharon Dwyer, Lelia M. Thornton, Peter J. Conlon

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

6 Citations (Scopus)

Abstract

We report the case of a 45-year-old haemodialysis patient who achieved a sustained virological response (SVR) following pegylated interferon therapy for hepatitis C virus (HCV) genotype 2 infection. He was subsequently cohorted with other HCV-infected dialysis patients and became re-infected with HCV genotype 3a. Epidemiological and molecular investigations identified a highly viraemic HCV genotype 3a-infected dialysis patient as the likely source of this infection. This critical incident informed a revision to local and national infection control policy regarding the dialysis management of patients who achieve an SVR following anti-viral treatment.

Original language	English
Pages (from-to)	250-253
Number of pages	4
Journal	Clinical Kidney Journal
Volume	5
Issue number	3
DOIs	https://doi.org/10.1093/ckj/sfs040
Publication status	Published - Jun 2012
Externally published	Yes

Keywords

dialysis
hepatitis C
infection control
re-infection
sustained virological response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ckj/sfs040

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title = "Re-infection following sustained virological response with a different hepatitis C virus genotype: Implications for infection control policy",

abstract = "We report the case of a 45-year-old haemodialysis patient who achieved a sustained virological response (SVR) following pegylated interferon therapy for hepatitis C virus (HCV) genotype 2 infection. He was subsequently cohorted with other HCV-infected dialysis patients and became re-infected with HCV genotype 3a. Epidemiological and molecular investigations identified a highly viraemic HCV genotype 3a-infected dialysis patient as the likely source of this infection. This critical incident informed a revision to local and national infection control policy regarding the dialysis management of patients who achieve an SVR following anti-viral treatment.",

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T1 - Re-infection following sustained virological response with a different hepatitis C virus genotype

T2 - Implications for infection control policy

AU - O'Shaughnessy, Michelle M.

AU - O'Regan, John A.

AU - Murray, Frank E.

AU - Connell, Jeff A.

AU - Duffy, Margaret P.

AU - Francis, Veronica M.

AU - Dwyer, Sharon

AU - Thornton, Lelia M.

AU - Conlon, Peter J.

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N2 - We report the case of a 45-year-old haemodialysis patient who achieved a sustained virological response (SVR) following pegylated interferon therapy for hepatitis C virus (HCV) genotype 2 infection. He was subsequently cohorted with other HCV-infected dialysis patients and became re-infected with HCV genotype 3a. Epidemiological and molecular investigations identified a highly viraemic HCV genotype 3a-infected dialysis patient as the likely source of this infection. This critical incident informed a revision to local and national infection control policy regarding the dialysis management of patients who achieve an SVR following anti-viral treatment.

AB - We report the case of a 45-year-old haemodialysis patient who achieved a sustained virological response (SVR) following pegylated interferon therapy for hepatitis C virus (HCV) genotype 2 infection. He was subsequently cohorted with other HCV-infected dialysis patients and became re-infected with HCV genotype 3a. Epidemiological and molecular investigations identified a highly viraemic HCV genotype 3a-infected dialysis patient as the likely source of this infection. This critical incident informed a revision to local and national infection control policy regarding the dialysis management of patients who achieve an SVR following anti-viral treatment.

KW - dialysis

KW - hepatitis C

KW - infection control

KW - re-infection

KW - sustained virological response

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Re-infection following sustained virological response with a different hepatitis C virus genotype: Implications for infection control policy

Abstract

Keywords

UN SDGs

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