Quasi-isothermal modulated DSC as a valuable characterisation method for soft tissue biomaterial crosslinking reactions

K. Joyce; S. Rahmani; Y. Rochev

doi:10.1016/j.bioactmat.2020.03.002

Quasi-isothermal modulated DSC as a valuable characterisation method for soft tissue biomaterial crosslinking reactions

K. Joyce
, S. Rahmani
, Y. Rochev

Biomedical Engineering

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

1 Citation (Scopus)

Abstract

Glutaraldehyde (Glut) is an extensively used sterilant and fixative for the crosslinking of natural soft tissue biomaterials like bovine pericardium (BP) to provide stability and is required for its application in vivo. There is plenty of debate around the reaction mechanism of Glut with natural biomaterials. Differential scanning calorimetry (DSC) is a commonly used technique that is typically used to measure the thermal profile of polymers. However, a variation known as quasi-isothermal modulated differential scanning calorimetry (QiMDSC) has been utilised for the analysis of polymorphic transformations in both the pharmaceutical and food industries. This communication will address QiMDSC as a method for analysing soft tissue biomaterials and their crosslinking mechanisms and how it can be applied to other biomaterial applications.

Original language	English
Pages (from-to)	428-434
Number of pages	7
Journal	Bioactive Materials
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.bioactmat.2020.03.002
Publication status	Published - 1 Jun 2020

Keywords

Bovine pericardium
Glutaraldehyde
QiMDSC

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Joyce, K;Rahmani, S;Rochev, Y

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10.1016/j.bioactmat.2020.03.002

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title = "Quasi-isothermal modulated DSC as a valuable characterisation method for soft tissue biomaterial crosslinking reactions",

abstract = "Glutaraldehyde (Glut) is an extensively used sterilant and fixative for the crosslinking of natural soft tissue biomaterials like bovine pericardium (BP) to provide stability and is required for its application in vivo. There is plenty of debate around the reaction mechanism of Glut with natural biomaterials. Differential scanning calorimetry (DSC) is a commonly used technique that is typically used to measure the thermal profile of polymers. However, a variation known as quasi-isothermal modulated differential scanning calorimetry (QiMDSC) has been utilised for the analysis of polymorphic transformations in both the pharmaceutical and food industries. This communication will address QiMDSC as a method for analysing soft tissue biomaterials and their crosslinking mechanisms and how it can be applied to other biomaterial applications.",

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AU - Joyce, K.

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AU - Rochev, Y.

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Y1 - 2020/6/1

N2 - Glutaraldehyde (Glut) is an extensively used sterilant and fixative for the crosslinking of natural soft tissue biomaterials like bovine pericardium (BP) to provide stability and is required for its application in vivo. There is plenty of debate around the reaction mechanism of Glut with natural biomaterials. Differential scanning calorimetry (DSC) is a commonly used technique that is typically used to measure the thermal profile of polymers. However, a variation known as quasi-isothermal modulated differential scanning calorimetry (QiMDSC) has been utilised for the analysis of polymorphic transformations in both the pharmaceutical and food industries. This communication will address QiMDSC as a method for analysing soft tissue biomaterials and their crosslinking mechanisms and how it can be applied to other biomaterial applications.

AB - Glutaraldehyde (Glut) is an extensively used sterilant and fixative for the crosslinking of natural soft tissue biomaterials like bovine pericardium (BP) to provide stability and is required for its application in vivo. There is plenty of debate around the reaction mechanism of Glut with natural biomaterials. Differential scanning calorimetry (DSC) is a commonly used technique that is typically used to measure the thermal profile of polymers. However, a variation known as quasi-isothermal modulated differential scanning calorimetry (QiMDSC) has been utilised for the analysis of polymorphic transformations in both the pharmaceutical and food industries. This communication will address QiMDSC as a method for analysing soft tissue biomaterials and their crosslinking mechanisms and how it can be applied to other biomaterial applications.

KW - Bovine pericardium

KW - Glutaraldehyde

KW - QiMDSC

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U2 - 10.1016/j.bioactmat.2020.03.002

DO - 10.1016/j.bioactmat.2020.03.002

M3 - Article

SN - 2452-199X

VL - 5

SP - 428

EP - 434

JO - Bioactive Materials

JF - Bioactive Materials

IS - 2

ER -

Quasi-isothermal modulated DSC as a valuable characterisation method for soft tissue biomaterial crosslinking reactions

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Keywords

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