Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Mahmoud Abdelshafy; Patrick W. Serruys; Tsung Ying Tsai; Pruthvi Chenniganahosahalli Revaiah; Scot Garg; Jean Paul Aben; Carl J. Schultz; Mohammad Abdelghani; Pim A.L. Tonino; Yosuke Miyazaki; Marcel C.M. Rutten; Martijn Cox; Cherif Sahyoun; Justin Teng; Hiroki Tateishi; Mohamed Abdel-Wahab; Nicolo Piazza; Michele Pighi; Rodrigo Modolo; Martijn van Mourik; Joanna Wykrzykowska; Robbert J. de Winter; Pedro A. Lemos; Fábio S. de Brito; Hideyuki Kawashima; Lars Søndergaard; Liesbeth Rosseel; Rutao Wang; Chao Gao; Ling Tao; Andreas Rück; Won Keun Kim; Niels van Royen; Christian J. Terkelsen; Henrik Nissen; Matti Adam; Tanja K. Rudolph; Hendrik Wienemann; Ryo Torii; Franz Josef Neuman; Simon Schoechlin; Mao Chen; Ahmed Elkoumy; Hesham Elzomor; Ignacio J. Amat-Santos; Darren Mylotte; Osama Soliman; Yoshinobu Onuma

doi:10.3389/fcvm.2023.1161779

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Mahmoud Abdelshafy
, Patrick W. Serruys
, Tsung Ying Tsai
, Pruthvi Chenniganahosahalli Revaiah
, Scot Garg
, Jean Paul Aben
, Carl J. Schultz
, Mohammad Abdelghani
, Pim A.L. Tonino
, Yosuke Miyazaki
, Marcel C.M. Rutten
, Martijn Cox
, Cherif Sahyoun
, Justin Teng
, Hiroki Tateishi
, Mohamed Abdel-Wahab
, Nicolo Piazza
, Michele Pighi
, Rodrigo Modolo
, Martijn van Mourik

Joanna Wykrzykowska, Robbert J. de Winter, Pedro A. Lemos, Fábio S. de Brito, Hideyuki Kawashima, Lars Søndergaard, Liesbeth Rosseel, Rutao Wang, Chao Gao, Ling Tao, Andreas Rück, Won Keun Kim, Niels van Royen, Christian J. Terkelsen, Henrik Nissen, Matti Adam, Tanja K. Rudolph, Hendrik Wienemann, Ryo Torii, Franz Josef Neuman, Simon Schoechlin, Mao Chen, Ahmed Elkoumy, Hesham Elzomor, Ignacio J. Amat-Santos, Darren Mylotte, Osama Soliman, Yoshinobu Onuma

Medicine

University of Galway
Al-Azhar University
Imperial College London
Royal Blackburn Hospital
Pie Medical Imaging
Royal Perth Hospital
The University of Western Australia
University of Amsterdam
Catharina Hospital
Yamaguchi University Graduate School of Medicine
Eindhoven University of Technology
Xeltis B.V.
Philips Healthcare Nederland
Shibata Hospital
Heart Centre Leipzig
McGill University
University of Verona
Boston Scientific Corporation
University Medical Center Groningen
University of São Paulo
Teikyo University School of Medicine
University Hospital of Copenhagen - Rigshospitalet
ASZ Hospital Aalst
Xijing Hospital
Karolinska Institutet
Kerckhoff Heart Center
Radboud University Nijmegen Medical Center
Aarhus University Hospital
Odense University Hospital
University of Cologne
Universitätsklinik der Ruhr-Universität Bochum
University College London
Universitäts-Herzzentrum Freiburg - Bad Krozingen
Sichuan University
Al-Azhar University
Hospital Clínico Universitario de Valladolid
National University of Ireland
Department of Cardiology
CORRIB Research Centre for Advanced Imaging and Core Laboratory
NHLI
Philips Oral Healthcare
Heart Center Leipzig at the University of Leipzig
McGill University
University of Verona
Boston Scientific
University Medical Centre
University of São Paulo Medical School (USP)
Copenhagen University Hospital
Department of Cardiology
The Fourth Military Medical University
Karolinska Institute
University of Cologne
Heart- und Diabetes Center NRW
University Heart Centre Freiburg-Bad Krozingen
Islamic Center of Cardiology and Cardiac Surgery

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

3 Citations (Scopus)

Abstract

Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.

Original language	English
Article number	1161779
Pages (from-to)	1161779
Journal	Frontiers in Cardiovascular Medicine
Volume	10
DOIs	https://doi.org/10.3389/fcvm.2023.1161779
Publication status	Published - 2023

Keywords

aortic regurgitation
paravalvular leak
quantitative aortography
transcatheter aortic valve implantation
transcatheter aortic valve replacement
videodensitometry

Access to Document

10.3389/fcvm.2023.1161779

Cite this

Abdelshafy, M., Serruys, P. W., Tsai, T. Y., Revaiah, P. C., Garg, S., Aben, J. P., Schultz, C. J., Abdelghani, M., Tonino, P. A. L., Miyazaki, Y., Rutten, M. C. M., Cox, M., Sahyoun, C., Teng, J., Tateishi, H., Abdel-Wahab, M., Piazza, N., Pighi, M., Modolo, R., ... Onuma, Y. (2023). Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement. Frontiers in Cardiovascular Medicine, 10, 1161779. Article 1161779. https://doi.org/10.3389/fcvm.2023.1161779

@article{4e69d5ed62544f08bf01c8a294594300,

title = "Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement",

abstract = "Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17\% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.",

keywords = "aortic regurgitation, paravalvular leak, quantitative aortography, transcatheter aortic valve implantation, transcatheter aortic valve replacement, videodensitometry",

author = "Mahmoud Abdelshafy and Serruys, \{Patrick W.\} and Tsai, \{Tsung Ying\} and Revaiah, \{Pruthvi Chenniganahosahalli\} and Scot Garg and Aben, \{Jean Paul\} and Schultz, \{Carl J.\} and Mohammad Abdelghani and Tonino, \{Pim A.L.\} and Yosuke Miyazaki and Rutten, \{Marcel C.M.\} and Martijn Cox and Cherif Sahyoun and Justin Teng and Hiroki Tateishi and Mohamed Abdel-Wahab and Nicolo Piazza and Michele Pighi and Rodrigo Modolo and \{van Mourik\}, Martijn and Joanna Wykrzykowska and \{de Winter\}, \{Robbert J.\} and Lemos, \{Pedro A.\} and de Brito, \{F{\'a}bio S.\} and Hideyuki Kawashima and Lars S{\o}ndergaard and Liesbeth Rosseel and Rutao Wang and Chao Gao and Ling Tao and Andreas R{\"u}ck and Kim, \{Won Keun\} and Royen, \{Niels van\} and Terkelsen, \{Christian J.\} and Henrik Nissen and Matti Adam and Rudolph, \{Tanja K.\} and Hendrik Wienemann and Ryo Torii and \{Josef Neuman\}, Franz and Simon Schoechlin and Mao Chen and Ahmed Elkoumy and Hesham Elzomor and Amat-Santos, \{Ignacio J.\} and Darren Mylotte and Osama Soliman and Yoshinobu Onuma",

note = "Publisher Copyright: 2023 Abdelshafy, Serruys, Tsai, Revaiah, Grag, Aben, Schultz, Abdelghani, Tonino, Miyazaki, Rutten, Cox, Sahyoun, Teng, Tateishi, Abdel-Wahab, Piazza, Pighi, Modolo, van Mourik, Wykrzykowska, de Wintet, Lemos, de Brito, Kawashima, S{\o}endergaard, Rosseel, Wang, Gao, Tao, R{\"u}ck, Kim, van Royen, Terkelsen, Nissen, Adam, Rudolph, Wienemann, Torii, Neuman, Schoechlin, Chen, Elkoumy, Elzomor, Amat-Santos, Mylotte, Soliman and Onuma.",

year = "2023",

doi = "10.3389/fcvm.2023.1161779",

language = "English",

volume = "10",

pages = "1161779",

journal = "Frontiers in Cardiovascular Medicine",

publisher = "Frontiers Media SA",

}

Abdelshafy, M, Serruys, PW, Tsai, TY, Revaiah, PC, Garg, S, Aben, JP, Schultz, CJ, Abdelghani, M, Tonino, PAL, Miyazaki, Y, Rutten, MCM, Cox, M, Sahyoun, C, Teng, J, Tateishi, H, Abdel-Wahab, M, Piazza, N, Pighi, M, Modolo, R, van Mourik, M, Wykrzykowska, J, de Winter, RJ, Lemos, PA, de Brito, FS, Kawashima, H, Søndergaard, L, Rosseel, L, Wang, R, Gao, C, Tao, L, Rück, A, Kim, WK, Royen, NV, Terkelsen, CJ, Nissen, H, Adam, M, Rudolph, TK, Wienemann, H, Torii, R, Josef Neuman, F, Schoechlin, S, Chen, M, Elkoumy, A, Elzomor, H, Amat-Santos, IJ, Mylotte, D, Soliman, O & Onuma, Y 2023, 'Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement', Frontiers in Cardiovascular Medicine, vol. 10, 1161779, pp. 1161779. https://doi.org/10.3389/fcvm.2023.1161779

TY - JOUR

T1 - Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

AU - Abdelshafy, Mahmoud

AU - Serruys, Patrick W.

AU - Tsai, Tsung Ying

AU - Revaiah, Pruthvi Chenniganahosahalli

AU - Garg, Scot

AU - Aben, Jean Paul

AU - Schultz, Carl J.

AU - Abdelghani, Mohammad

AU - Tonino, Pim A.L.

AU - Miyazaki, Yosuke

AU - Rutten, Marcel C.M.

AU - Cox, Martijn

AU - Sahyoun, Cherif

AU - Teng, Justin

AU - Tateishi, Hiroki

AU - Abdel-Wahab, Mohamed

AU - Piazza, Nicolo

AU - Pighi, Michele

AU - Modolo, Rodrigo

AU - van Mourik, Martijn

AU - Wykrzykowska, Joanna

AU - de Winter, Robbert J.

AU - Lemos, Pedro A.

AU - de Brito, Fábio S.

AU - Kawashima, Hideyuki

AU - Søndergaard, Lars

AU - Rosseel, Liesbeth

AU - Wang, Rutao

AU - Gao, Chao

AU - Tao, Ling

AU - Rück, Andreas

AU - Kim, Won Keun

AU - Royen, Niels van

AU - Terkelsen, Christian J.

AU - Nissen, Henrik

AU - Adam, Matti

AU - Rudolph, Tanja K.

AU - Wienemann, Hendrik

AU - Torii, Ryo

AU - Josef Neuman, Franz

AU - Schoechlin, Simon

AU - Chen, Mao

AU - Elkoumy, Ahmed

AU - Elzomor, Hesham

AU - Amat-Santos, Ignacio J.

AU - Mylotte, Darren

AU - Soliman, Osama

AU - Onuma, Yoshinobu

N1 - Publisher Copyright: 2023 Abdelshafy, Serruys, Tsai, Revaiah, Grag, Aben, Schultz, Abdelghani, Tonino, Miyazaki, Rutten, Cox, Sahyoun, Teng, Tateishi, Abdel-Wahab, Piazza, Pighi, Modolo, van Mourik, Wykrzykowska, de Wintet, Lemos, de Brito, Kawashima, Søendergaard, Rosseel, Wang, Gao, Tao, Rück, Kim, van Royen, Terkelsen, Nissen, Adam, Rudolph, Wienemann, Torii, Neuman, Schoechlin, Chen, Elkoumy, Elzomor, Amat-Santos, Mylotte, Soliman and Onuma.

PY - 2023

Y1 - 2023

N2 - Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.

AB - Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.

KW - aortic regurgitation

KW - paravalvular leak

KW - quantitative aortography

KW - transcatheter aortic valve implantation

KW - transcatheter aortic valve replacement

KW - videodensitometry

UR - https://www.scopus.com/pages/publications/85166427979

U2 - 10.3389/fcvm.2023.1161779

DO - 10.3389/fcvm.2023.1161779

M3 - Review article

C2 - 37529710

VL - 10

SP - 1161779

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 1161779

ER -

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this