TY - JOUR
T1 - Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement
AU - Abdelshafy, Mahmoud
AU - Serruys, Patrick W
AU - Tsai, Tsung-Ying
AU - Revaiah, Pruthvi Chenniganahosahalli
AU - Garg, Scot
AU - Aben, Jean-Paul
AU - Schultz, Carl J
AU - Abdelghani, Mohammad
AU - Tonino, Pim A L
AU - Miyazaki, Yosuke
AU - Rutten, Marcel C M
AU - Cox, Martijn
AU - Sahyoun, Cherif
AU - Teng, Justin
AU - Tateishi, Hiroki
AU - Abdel-Wahab, Mohamed
AU - Piazza, Nicolo
AU - Pighi, Michele
AU - Modolo, Rodrigo
AU - van Mourik, Martijn
AU - Wykrzykowska, Joanna
AU - de Winter, Robbert J
AU - Lemos, Pedro A
AU - de Brito, Fábio S
AU - Kawashima, Hideyuki
AU - Søndergaard, Lars
AU - Rosseel, Liesbeth
AU - Wang, Rutao
AU - Gao, Chao
AU - Tao, Ling
AU - Rück, Andreas
AU - Kim, Won-Keun
AU - van Royen, Niels
AU - Terkelsen, Christian J
AU - Nissen, Henrik
AU - Adam, Matti
AU - Rudolph, Tanja K
AU - Wienemann, Hendrik
AU - Torii, Ryo
AU - Josef Neuman, Franz
AU - Schoechlin, Simon
AU - Chen, Mao
AU - Elkoumy, Ahmed
AU - Elzomor, Hesham
AU - Amat-Santos, Ignacio J
AU - Mylotte, Darren
AU - Soliman, Osama
AU - Onuma, Yoshinobu
N1 - © 2023 Abdelshafy, Serruys, Tsai, Revaiah, Grag, Aben, Schultz, Abdelghani, Tonino, Miyazaki, Rutten, Cox, Sahyoun, Teng, Tateishi, Abdel-Wahab, Piazza, Pighi, Modolo, van Mourik, Wykrzykowska, de Wintet, Lemos, de Brito, Kawashima, Søendergaard, Rosseel, Wang, Gao, Tao, Rück, Kim, van Royen, Terkelsen, Nissen, Adam, Rudolph, Wienemann, Torii, Neuman, Schoechlin, Chen, Elkoumy, Elzomor, Amat-Santos, Mylotte, Soliman and Onuma.
PY - 2023
Y1 - 2023
N2 - Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.
AB - Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.
U2 - 10.3389/fcvm.2023.1161779
DO - 10.3389/fcvm.2023.1161779
M3 - Review article
C2 - 37529710
SN - 2297-055X
VL - 10
SP - 1161779
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
ER -