Pyroglutamate-derived hydroxyamide ligands: Synthesis and application to asymmetric catalysis

Paul Geoghegan; Patrick O'Leary

doi:10.1016/j.tetasy.2010.04.055

Pyroglutamate-derived hydroxyamide ligands: Synthesis and application to asymmetric catalysis

Paul Geoghegan, Patrick O'Leary

Physics

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

12 Citations (Scopus)

Abstract

The synthesis of a series of chiral hydroxy amide ligands is described. These ligands were used in a ruthenium-catalysed transfer hydrogenation reaction where one ligand gave the product in 72% ee. The ligands were also used in two titanium-catalysed reactions, an alkylation where ee's of up to 74% were achieved and a phenyl acetylene addition where more modest selectivities were observed.

Original language	English
Pages (from-to)	867-870
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.tetasy.2010.04.055
Publication status	Published - 21 Apr 2010

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Authors
Geoghegan, P;O'Leary, P

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10.1016/j.tetasy.2010.04.055

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title = "Pyroglutamate-derived hydroxyamide ligands: Synthesis and application to asymmetric catalysis",

abstract = "The synthesis of a series of chiral hydroxy amide ligands is described. These ligands were used in a ruthenium-catalysed transfer hydrogenation reaction where one ligand gave the product in 72\% ee. The ligands were also used in two titanium-catalysed reactions, an alkylation where ee's of up to 74\% were achieved and a phenyl acetylene addition where more modest selectivities were observed.",

author = "Paul Geoghegan and Patrick O'Leary",

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T1 - Pyroglutamate-derived hydroxyamide ligands

T2 - Synthesis and application to asymmetric catalysis

AU - Geoghegan, Paul

AU - O'Leary, Patrick

PY - 2010/4/21

Y1 - 2010/4/21

N2 - The synthesis of a series of chiral hydroxy amide ligands is described. These ligands were used in a ruthenium-catalysed transfer hydrogenation reaction where one ligand gave the product in 72% ee. The ligands were also used in two titanium-catalysed reactions, an alkylation where ee's of up to 74% were achieved and a phenyl acetylene addition where more modest selectivities were observed.

AB - The synthesis of a series of chiral hydroxy amide ligands is described. These ligands were used in a ruthenium-catalysed transfer hydrogenation reaction where one ligand gave the product in 72% ee. The ligands were also used in two titanium-catalysed reactions, an alkylation where ee's of up to 74% were achieved and a phenyl acetylene addition where more modest selectivities were observed.

UR - https://www.scopus.com/pages/publications/77956466741

U2 - 10.1016/j.tetasy.2010.04.055

DO - 10.1016/j.tetasy.2010.04.055

M3 - Article

SN - 0957-4166

VL - 21

SP - 867

EP - 870

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 7

ER -

Pyroglutamate-derived hydroxyamide ligands: Synthesis and application to asymmetric catalysis

Abstract

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