Protein assembly mediated by sulfonatocalix[4]arene

Róise E. McGovern; Andrew A. McCarthy; Peter B. Crowley

doi:10.1039/c4cc04897k

Protein assembly mediated by sulfonatocalix[4]arene

Róise E. McGovern, Andrew A. McCarthy, Peter B. Crowley

Cellular & Molecular Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

83 Citations (Scopus)

Abstract

A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx₄) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx₄, Mg²⁺ and a fragment of polyethylene glycol.

Original language	English
Pages (from-to)	10412-10415
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	72
DOIs	https://doi.org/10.1039/c4cc04897k
Publication status	Published - 12 Aug 2014

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title = "Protein assembly mediated by sulfonatocalix[4]arene",

abstract = "A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg2+ and a fragment of polyethylene glycol.",

author = "McGovern, \{R{\'o}ise E.\} and McCarthy, \{Andrew A.\} and Crowley, \{Peter B.\}",

year = "2014",

month = aug,

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doi = "10.1039/c4cc04897k",

language = "English",

volume = "50",

pages = "10412--10415",

journal = "Chemical Communications",

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T1 - Protein assembly mediated by sulfonatocalix[4]arene

AU - McGovern, Róise E.

AU - McCarthy, Andrew A.

AU - Crowley, Peter B.

PY - 2014/8/12

Y1 - 2014/8/12

N2 - A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg2+ and a fragment of polyethylene glycol.

AB - A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg2+ and a fragment of polyethylene glycol.

UR - https://www.scopus.com/pages/publications/84906251082

U2 - 10.1039/c4cc04897k

DO - 10.1039/c4cc04897k

M3 - Article

SN - 1359-7345

VL - 50

SP - 10412

EP - 10415

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Protein assembly mediated by sulfonatocalix[4]arene

Abstract

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