Programmiruemaia gibel' kletok timomy myshi BW5147 pod deǐstviem deksametazona.

I. I. Kruman; N. P. Matylevich; I. A. Rochev; I. P. Beletskiǐ; V. N. Afanas'ev; S. R. Umanskiǐ

Programmiruemaia gibel' kletok timomy myshi BW5147 pod deǐstviem deksametazona.

Translated title of the contribution: The programmed cell death of murine BW5147 thymoma under the action of dexamethasone

I. I. Kruman
, N. P. Matylevich
, I. A. Rochev
, I. P. Beletskiǐ
, V. N. Afanas'ev
, S. R. Umanskiǐ

Biomedical Engineering

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

1 Citation (Scopus)

Abstract

By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation.

Translated title of the contribution	The programmed cell death of murine BW5147 thymoma under the action of dexamethasone
Original language	Russian
Pages (from-to)	43-53
Number of pages	11
Journal	Tsitologiya
Volume	34
Issue number	2
Publication status	Published - 1992

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@article{c679dd82ba324196ba6769b79e288871,

title = "Programmiruemaia gibel' kletok timomy myshi BW5147 pod deǐstviem deksametazona.",

abstract = "By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2\%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation.",

author = "Kruman, \{I. I.\} and Matylevich, \{N. P.\} and Rochev, \{I. A.\} and Beletskiǐ, \{I. P.\} and Afanas'ev, \{V. N.\} and Umanskiǐ, \{S. R.\}",

year = "1992",

language = "Russian",

volume = "34",

pages = "43--53",

journal = "Tsitologiya",

issn = "0041-3771",

publisher = "Russian Academy of Sciences, Institute Of Cytology",

number = "2",

}

TY - JOUR

T1 - Programmiruemaia gibel' kletok timomy myshi BW5147 pod deǐstviem deksametazona.

AU - Kruman, I. I.

AU - Matylevich, N. P.

AU - Rochev, I. A.

AU - Beletskiǐ, I. P.

AU - Afanas'ev, V. N.

AU - Umanskiǐ, S. R.

PY - 1992

Y1 - 1992

N2 - By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation.

AB - By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation.

UR - https://www.scopus.com/pages/publications/0026436671

M3 - Article

SN - 0041-3771

VL - 34

SP - 43

EP - 53

JO - Tsitologiya

JF - Tsitologiya

IS - 2

ER -

Programmiruemaia gibel' kletok timomy myshi BW5147 pod deǐstviem deksametazona.

Abstract

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