Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology?

Amir Ahmadi; Gregg W. Stone; Jonathon Leipsic; Leslee J. Shaw; Todd C. Villines; Morton J. Kern; Harvey Hecht; David Erlinge; Ori Ben-Yehuda; Akiko Maehara; Eloisa Arbustini; Patrick Serruys; Hector M. Garcia-Garcia; Jagat Narula

doi:10.1161/CIRCRESAHA.116.308952

Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology?

Amir Ahmadi
, Gregg W. Stone
, Jonathon Leipsic
, Leslee J. Shaw
, Todd C. Villines
, Morton J. Kern
, Harvey Hecht
, David Erlinge
, Ori Ben-Yehuda
, Akiko Maehara
, Eloisa Arbustini
, Patrick Serruys
, Hector M. Garcia-Garcia
, Jagat Narula

Icahn School of Medicine at Mount Sinai
University of British Columbia
Columbia University Medical Center
Emory University School of Medicine
Walter Reed National Military Medical Center
University of California, Irvine
Lund University
University of California San Diego
IRCCS Policlinico San Matteo
Imperial College London
Leesburg Regional Medical Centre

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

46 Citations (Scopus)

Abstract

Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

Original language	English
Pages (from-to)	317-329
Number of pages	13
Journal	Circulation Research
Volume	119
Issue number	2
DOIs	https://doi.org/10.1161/CIRCRESAHA.116.308952
Publication status	Published - 8 Jul 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

coronary artery disease
fractional flow reserve
multidetector computed tomography
myocardial ischemia
plaque, atherosclerotic

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10.1161/CIRCRESAHA.116.308952

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Ahmadi, A., Stone, G. W., Leipsic, J., Shaw, L. J., Villines, T. C., Kern, M. J., Hecht, H., Erlinge, D., Ben-Yehuda, O., Maehara, A., Arbustini, E., Serruys, P., Garcia-Garcia, H. M., & Narula, J. (2016). Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology? Circulation Research, 119(2), 317-329. https://doi.org/10.1161/CIRCRESAHA.116.308952

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title = "Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology?",

abstract = "Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.",

keywords = "coronary artery disease, fractional flow reserve, multidetector computed tomography, myocardial ischemia, plaque, atherosclerotic",

author = "Amir Ahmadi and Stone, \{Gregg W.\} and Jonathon Leipsic and Shaw, \{Leslee J.\} and Villines, \{Todd C.\} and Kern, \{Morton J.\} and Harvey Hecht and David Erlinge and Ori Ben-Yehuda and Akiko Maehara and Eloisa Arbustini and Patrick Serruys and Garcia-Garcia, \{Hector M.\} and Jagat Narula",

note = "Publisher Copyright: {\textcopyright} 2016 American Heart Association, Inc.",

year = "2016",

month = jul,

day = "8",

doi = "10.1161/CIRCRESAHA.116.308952",

language = "English",

volume = "119",

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journal = "Circulation Research",

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Ahmadi, A, Stone, GW, Leipsic, J, Shaw, LJ, Villines, TC, Kern, MJ, Hecht, H, Erlinge, D, Ben-Yehuda, O, Maehara, A, Arbustini, E, Serruys, P, Garcia-Garcia, HM & Narula, J 2016, 'Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology?', Circulation Research, vol. 119, no. 2, pp. 317-329. https://doi.org/10.1161/CIRCRESAHA.116.308952

TY - JOUR

T1 - Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease

T2 - Anatomy, Physiology, or Morphology?

AU - Ahmadi, Amir

AU - Stone, Gregg W.

AU - Leipsic, Jonathon

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Kern, Morton J.

AU - Hecht, Harvey

AU - Erlinge, David

AU - Ben-Yehuda, Ori

AU - Maehara, Akiko

AU - Arbustini, Eloisa

AU - Serruys, Patrick

AU - Garcia-Garcia, Hector M.

AU - Narula, Jagat

PY - 2016/7/8

Y1 - 2016/7/8

N2 - Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

AB - Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

KW - coronary artery disease

KW - fractional flow reserve

KW - multidetector computed tomography

KW - myocardial ischemia

KW - plaque, atherosclerotic

UR - https://www.scopus.com/pages/publications/84978154344

U2 - 10.1161/CIRCRESAHA.116.308952

DO - 10.1161/CIRCRESAHA.116.308952

M3 - Review article

C2 - 27390334

AN - SCOPUS:84978154344

SN - 0009-7330

VL - 119

SP - 317

EP - 329

JO - Circulation Research

JF - Circulation Research

IS - 2

ER -

Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology?

Abstract

UN SDGs

Keywords

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