Probing the determinants of porosity in protein frameworks: Co-crystals of cytochrome: C and an octa-anionic calix[4]arene

Jimi M. Alex; Giovanna Brancatelli; Stefano Volpi; Carmela Bonaccorso; Alessandro Casnati; Silvano Geremia; Peter B. Crowley

doi:10.1039/c9ob02275a

Probing the determinants of porosity in protein frameworks: Co-crystals of cytochrome: C and an octa-anionic calix[4]arene

Jimi M. Alex, Giovanna Brancatelli, Stefano Volpi, Carmela Bonaccorso, Alessandro Casnati, Silvano Geremia, Peter B. Crowley

Cellular & Molecular Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

18 Citations (Scopus)

Abstract

Sulfonato-calix[n]arenes (sclx_n) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx₄mc) in complex with proteins. Two crystal structures of sclx₄mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx₈ and sclx₆ but not with sclx₄, suggesting that the ligand charge is a determining factor.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	18
Issue number	2
DOIs	https://doi.org/10.1039/c9ob02275a
Publication status	Published - 2020

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abstract = "Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.",

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AU - Volpi, Stefano

AU - Bonaccorso, Carmela

AU - Casnati, Alessandro

AU - Geremia, Silvano

AU - Crowley, Peter B.

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AB - Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.

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Probing the determinants of porosity in protein frameworks: Co-crystals of cytochrome: C and an octa-anionic calix[4]arene

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